Results 71 to 80 of about 167,996,906 (262)

Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts

, 2022
This work represents the first systematic analysis of kinetochore assembly in human mitotic cell extracts. Using recombinant and native proteins, we show that only a few assembly steps are permitted, suggesting that multiple mechanisms guard against the
Grishchuk, Ekaterina L, Black, Ben E, Tarasovetc, Ekaterina V, Wimbish, Robert T, Cheeseman, Iain M, Allu, Praveen Kumar, DeLuca, Jennifer G   +6 more
core   +1 more source

Interactive Multiresolution Visualization of Cellular Network Processes

iScience, 2020
Summary: Visualization plays a central role in the analysis of biochemical network models to identify patterns that arise from reaction dynamics and perform model exploratory analysis.
Oscar O. Ortega, Carlos F. Lopez
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma

iScience
Summary: Brain metastases (BM) of lung adenocarcinoma (LUAD) are the most common intracranial malignancy leading to death. However, the cellular origins and drivers of BM from LUAD have not been clarified. Cellular composition was characterized by single-
Yonghui Wu, Fujun Yang, Shilan Luo, Xiang Li, Zhan Gu, Rui Fan, Yajuan Cao, Lixin Wang, Xiao Song   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors

iScience
Summary: Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance.
Eun-Ji Kwon, Hyuk-Jin Cha, Haeseung Lee
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Tyrosine Phosphatase CD148 is Excluded from the Immunologic Synapse and Down-regulates Prolonged T Cell Signaling [PDF]

, 2003
?? Joseph Lin and Arthur Weis, 2011. Originally published in The Journal of Cell Biology. doi: 10.1083/jcb.200303040.CD148 is a receptor-like protein tyrosine phosphatase\ud up-regulated on T cells after T cell receptor\ud (TCR) stimulation.
Arthur Weiss, Weiss, Arthur, Lin, Joseph, Joseph Lin   +3 more
core   +1 more source

TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells

iScience
Summary: Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV infection
Yuling Sun, Huidi Yu, Zhihao Zhan, Wei Liu, Penggang Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu   +9 more
doaj   +1 more source