Results 51 to 60 of about 167,996,906 (262)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S   +30 more
core   +1 more source

PD-LI promotes rear retraction during persistent cell migration by altering integrin β4 dynamics

, 2022
Although the immune checkpoint function of PD-L1 has dominated its study, we report that PD-L1 has an unanticipated intrinsic function in promoting the dynamics of persistent cell migration.
Wang, Mengdie, Mercurio, Arthur M., Xiong, Choua   +2 more
core   +1 more source

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

iScience
Summary: The application of single-cell technologies in clinical nephrology remains elusive. We generated an atlas of transcriptionally defined cell types and cell states of human kidney disease by integrating single-cell signatures reported in the ...
David Legouis, Anna Rinaldi, Daniele Malpetti, Gregoire Arnoux, Thomas Verissimo, Anna Faivre, Francesca Mangili, Andrea Rinaldi, Lorenzo Ruinelli, Jerome Pugin, Solange Moll, Luca Clivio, Marco Bolis, Sophie de Seigneux, Laura Azzimonti, Pietro E. Cippà   +15 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation

iScience, 2020
Summary: Although the dynamic features of type I coherent feedforward loop (C1-FFL) has been well studied, how C1-FFL shapes cell-to-cell heterogeneity remains unclear.
Jie Zhou, Tingzhe Sun, Shouheng Jin, Zhiyong Guo, Jun Cui   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Phosphorylation controls autoinhibition of cytoplasmic linker protein-170 [PDF]

, 2010
Author Posting. © American Society for Cell Biology, 2010. This article is posted here by permission of American Society for Cell Biology for personal use, not for redistribution. The definitive version was published in Molecular Biology of the Cell 21
Lee, Ho-Sup, Jeffrey van Haren, Schober, J.M. (Joseph), Borisy, G.G. (Gary), Ho-sup Lee, Komarova, Y. (Yulia), John G. Peloquin, Borisy, Gary G, Danciu, O. (Oana), Nadezhdina, Elena S., van Haren, Jeffrey, Gary G. Borisy, Steven P. Gygi, Akhmanova, A.S. (Anna), van Haren, Jeffrey; id_orcid, Peloquin, J.G. (John), Galjart, Niels; id_orcid, Niels Galjart, Nadezhdina, E. (Elena), Nadezhdina, Elena S, Anjum, R. (Rana), Yulia A. Komarova, Joseph M. Schober, Komarova, Yulia A, Borisy, Gary G., Rana Anjum, Elena S. Nadezhdina, Oana Danciu, Haren, J.A.J. (Jeffrey) van, Anna Akhmanova, Peloquin, John G, Peloquin, John G., Anjum, Rana, Gygi, Steven P., Lee, H.S. (Hahn), Galjart, N.J. (Niels), Schober, Joseph M, Gygi, Steven P, Komarova, Yulia A., Schober, Joseph M., Danciu, Oana, Galjart, Niels, Gygi, S.P. (Steven), Akhmanova, Anna   +43 more
core   +1 more source

Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia

iScience
Summary: Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway ...
Jacqueline E. Taudien, Diana Bracht, Heike Olbrich, Sebastian Swirski, Fulvio D’Abrusco, Bert Van der Zwaag, Maike Möller, Thomas Lücke, Norbert Teig, Ulrika Lindberg, Kai Wohlgemuth, Julia Wallmeier, Anja Blanque, Christos Gatsogiannis, Sebastian George, Christoph Jüschke, Marta Owczarek-Lipska, Dorothee Veer, Hester Y. Kroes, Enza Maria Valente, G. Christoph Korenke, Heymut Omran, John Neidhardt   +22 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dynamic cell cycle–dependent phosphorylation modulates CENP-L–CENP-N centromere recruitment

, 2022
The kinetochore is a macromolecular structure that is needed to ensure proper chromosome segregation during each cellular division. The kinetochore is assembled upon a platform of the 16-subunit constitutive centromere-associated network (CCAN), which is
Cheeseman, Iain M., Navarro, Alexandra P, Cheeseman, Iain M, Navarro, Alexandra P.   +3 more
core   +1 more source