Results 41 to 50 of about 167,996,906 (262)
STAT3 drives the expression of ACSL4 in acute kidney injury
iScienceSummary: Long-chain acyl-CoA synthetase family 4 (ACSL4) metabolizes long-chain polyunsaturated fatty acids (PUFAs), enriching cell membranes with phospholipids susceptible to peroxidation and drive ferroptosis.
Virginie Poindessous +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Cell biology of fat storage [PDF]
, 2016 The worldwide epidemic of obesity and type 2 diabetes has greatly increased interest in the biology and physiology of adipose tissues. Adipose (fat) cells are specialized for the storage of energy in the form of triglycerides, but research in the last ...
Cohen, Paul, Spiegelman, Bruce
core +1 more source
Single-cell transcriptome atlas of adult male and female human hookworm Ancylostoma ceylanicum
iScienceSummary: Hookworms infect over 500 million people globally and are a major neglected tropical disease. Their high prevalence and reinfection rates, combined with emerging drug resistance, highlight the need for new therapeutic or vaccine targets.
Suman Bharti +3 more
doaj +1 more source
Integrative modeling of the cell
Acta Biochimica et Biophysica Sinica, 2022 A whole-cell model represents certain aspects of the cell structure and/or function. Due to the high complexity of the cell, an integrative modeling approach is often taken to utilize all available information including experimental data, prior knowledge
Zhong Xianni, Zhao Jihui, Sun Liping
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]
, 2006 A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G +14 more
core +1 more source
A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq
iScienceSummary: Understanding the cellular characteristics and regulatory networks of cells during the growth of human liver organoids is crucial for comprehending liver development and function.
Qinfeng Ma, Xu Zhang, Jianbo Pan
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2015 One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.
Murphy, Coleen T, DiLoreto, Race
core +1 more source