Results 21 to 30 of about 145,713 (206)

An integrative view on glucagon function and putative role in the progression of pancreatic neuroendocrine tumours (pNETs) and hepatocellular carcinomas (HCC).

Molecular and Cellular Endocrinology, 2023
Cancer metabolism research area evolved greatly, however, is still unknown the impact of systemic metabolism control and diet on cancer. It makes sense that systemic regulators of metabolism can act directly on cancer cells and activate signalling ...
Bárbara Ferreira, Adriana Heredia, J. Serpa   +2 more
semanticscholar   +1 more source

Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology

Blood, 2020
BACKGROUND: Follicular lymphoma (FL) is an indolent malignancy of germinal center B-cell origin. FL patients experience remarkable heterogeneity in their disease trajectory, with many patients slowly progressing over several years, and a subset of patients experiencing an aggressive clinical course.
Andrea J. Radtke, Arthur L. Shaffer, Stefania Pittaluga, Alexander Bagaev, Nishant Thakur, Theresa Davies-Hill, Olga Plotnikova, Ilia Galkin, Ekaterina Postovalova, Viktor Svekolkin, Sergei Isaev, Yaroslav Lozinsky, Mark Meerson, Arina Varlamova, Pavel Ovcharov, Margarita Polyakova, Krystle Nomie, Ekaterina Nuzhdina, Nikita Kotlov, Maria Tsiper, Felix Frenkel, Ravshan Attaulakhanov, Nathan H Fowler, Ziv Yaniv, Bradley C Lowekamp, Michael Kelly, Ezzat Dadkhah, Da Wei Huang, Jagan R. Muppidi, Elaine S. Jaffe, Wyndham H. Wilson, Louis M. Staudt, Ronald N. Germain, Mark Roschewski   +33 more
openaire   +1 more source

Mycosis Fungoides and Sézary Syndrome: An Integrative Review of the Pathophysiology, Molecular Drivers, and Targeted Therapy

Cancers, 2021
Simple Summary In the last few years, the field of cutaneous T-cell lymphomas has experienced major advances. In the context of an active translational and clinical research field, next-generation sequencing data have boosted our understanding of the ...
Nuria García-Díaz, M. Piris, P. Ortiz-Romero, J. Vaqué   +3 more
semanticscholar   +1 more source

Population dynamics of EMT elucidates the timing and distribution of phenotypic intra-tumoral heterogeneity

iScience, 2023
Summary: The Epithelial-to-Mesenchymal Transition (EMT) is a hallmark of cancer metastasis and morbidity. EMT is a non-binary process, and cells can be stably arrested en route to EMT in an intermediate hybrid state associated with enhanced tumor ...
Annice Najafi, Mohit K. Jolly, Jason T. George   +2 more
doaj   +1 more source

Identification of lysine-lactylated substrates in gastric cancer cells

iScience, 2022
Summary: Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM)
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding   +5 more
doaj   +1 more source

Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology

Frontiers in Immunology, 2021
The scopes related to the interplay between stem cells and the immune system are broad and range from the basic understanding of organism’s physiology and ecology to translational studies, further contributing to (eco)toxicology, biotechnology, and ...
L. Ballarin, A. Karahan, A. Salvetti, L. Rossi, L. Manni, B. Rinkevich, A. Rosner, A. Voskoboynik, B. Rosental, L. Canesi, C. Anselmi, A. Pinsino, Begüm Ece Tohumcu, Anita Jemec Kokalj, Andraž Dolar, Sara Novak, M. Sugni, I. Corsi, D. Drobne   +18 more
semanticscholar   +1 more source

Constraint-based modeling of yeast mitochondria reveals the dynamics of protein import and iron-sulfur cluster biogenesis

iScience, 2021
Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina, Francesca Di Bartolomeo, Eduard J. Kerkhoven, Jens Nielsen   +3 more
doaj   +1 more source

Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem, Bali Pulendran, Rino Rappuoli, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +5 more sources

A zinc transporter gene required for development of the nervous system. [PDF]

, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo, Graham, David M, Keen, Carl L, Messerli, Mark A, Rucker, Robert B   +4 more
core   +1 more source

Integrative biology of native cell extracts: a new era for structural characterization of life processes

Biological chemistry, 2019
Advances in electron microscopy have provided unprecedented access to the structural characterization of large, flexible and heterogeneous complexes. Until recently, cryo-electron microscopy (cryo-EM) has been applied to understand molecular organization
F. L. Kyrilis, A. Meister, P. Kastritis
semanticscholar   +1 more source