Results 11 to 20 of about 145,713 (206)
Integrative modeling of the cell
Acta Biochimica et Biophysica Sinica, 2022 A whole-cell model represents certain aspects of the cell structure and/or function. Due to the high complexity of the cell, an integrative modeling approach is often taken to utilize all available information including experimental data, prior knowledge
Zhong Xianni, Zhao Jihui, Sun Liping
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Angle-Based Joint and Individual Variation Explained [PDF]
Journal of Multivariate Analysis, 2018 Integrative analysis of disparate data blocks measured on a common set of experimental subjects is a major challenge in modern data analysis. This data structure naturally motivates the simultaneous exploration of the joint and individual variation ...
Feng, Qing +3 more
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The Role of Spastin in Axon Biology
Frontiers in Cell and Developmental Biology, 2022 Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa +2 more
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Recent progress and future challenges in algal biofuel production [version 1; referees: 4 approved]
F1000Research, 2016 Modern society is fueled by fossil energy produced millions of years ago by photosynthetic organisms. Cultivating contemporary photosynthetic producers to generate energy and capture carbon from the atmosphere is one potential approach to sustaining ...
Jonathan B. Shurin +3 more
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Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
iScience, 2023 Summary: G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma membrane signaling proteins. However, virtually nothing is known about their recruitment to COPII vesicles for forward delivery after synthesis in the endoplasmic ...
Xin Xu, Nevin A. Lambert, Guangyu Wu
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Journal of the Royal Society Interface, 2022 Microbial populations often contain persister cells, which reduce the extinction risk upon sudden stresses. Persister cell formation is deeply intertwined with physiology. Due to this complexity, it cannot be satisfactorily understood by focusing only on
Alicia Berkvens +2 more
semanticscholar +1 more source
Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
iScience, 2021 Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer ...
Liang Guo +8 more
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A fatal affair: Circulating tumor cell relationships that shape metastasis
iScience, 2021 Summary: Circulating tumor cells are metastatic precursors in several cancer types. Their biology and clinical utility are subject to numerous investigations, yet one aspect that is often neglected is their entanglement with the tumor microenvironment ...
Lauren L. Ozimski +2 more
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Contribution of septins to human platelet structure and function
iScience, 2022 Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim +5 more
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Glycosylation network mapping and site-specific glycan maturation in vivo
iScience, 2022 Summary: Glycoprotein processing along a complex highly compartmentalized pathway is a hallmark of eukaryotic cells. We followed the kinetics of intracellular, site-specific glycan processing of a model protein with five distinct N-glycosylation sites ...
Marie-Estelle Losfeld +3 more
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