Results 11 to 20 of about 41,506 (219)

Repression of G1/S Transition by Transient Inhibition of miR-10404 Expression in Drosophila Primordial Germ Cells

iScience, 2020
Summary: Cell-cycle quiescence is a common feature of early germline development in many animal species. In Drosophila germline progenitors (pole cells), both G2/M and G1/S transitions are blocked.
Shumpei Morita, Ryoma Ota, Makoto Hayashi, Satoru Kobayashi   +3 more
doaj   +1 more source

Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron

iScience, 2023
Summary: Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood.
Allison L. Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A. Paulo, Beata Małachowska, Xia Xiao, Wojciech Fendler, Joseph D. Mancias, Jodie L. Babitt   +9 more
doaj   +1 more source

Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap

iScience, 2020
Summary: Integration of transforming growth factor β (TGF-β) signals with those of other pathways allows for precise temporal and spatial control of gene expression patterns that drive development and homeostasis. The Hippo pathway nuclear effectors, Taz/
Bita Labibi, Mikhail Bashkurov, Jeffrey L. Wrana, Liliana Attisano   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design

npj Vaccines
The promises of vaccines based on virus-like particles stimulate demand for universal non-infectious virus-like platforms that can be efficiently grafted with large antigens.
Emeline Vernhes, Linda Larbi Chérif, Nicolas Ducrot, Clément Vanbergue, Malika Ouldali, Lena Zig, N’diaye Sidibe, Sylviane Hoos, Luis Ramirez-Chamorro, Madalena Renouard, Ombeline Rossier, Patrick England, Guy Schoehn, Pascale Boulanger, Karim Benihoud   +14 more
doaj   +1 more source

Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions

iScience
Summary: The mechanisms underlying the pathophysiology of endometriosis, characterized by the presence of endometrium-like tissue outside the uterus, remain poorly understood.
Gregory W. Burns, Zhen Fu, Erin L. Vegter, Zachary B. Madaj, Erin Greaves, Idhaliz Flores, Asgerally T. Fazleabas   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Primary and metastatic cellular landscapes in human pancreatic cancer

iScience
Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a complex tumor microenvironment (TME). We utilized single cell RNA sequencing to compare the TMEs of metastatic sites and primary tumors.
Nina G. Steele, Veerin R. Sirihorachai, Ahmed M. Elhossiny, Ian M. Loveless, Padma Kadiyala, Monica Bonilla, Emily L. Lasse-Opsahl, Carinna Solano Vargas, Katelyn L. Donahue, Samantha B. Kemp, Valerie Gunchick, Yatrik M. Shah, Timothy L. Frankel, Filip Bednar, Arvind Rao, Benjamin L. Allen, Jiaqi Shi, Vaibhav Sahai, Howard C. Crawford, Eileen S. Carpenter, Marina Pasca di Magliano   +20 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

STAT3 drives the expression of ACSL4 in acute kidney injury

iScience
Summary: Long-chain acyl-CoA synthetase family 4 (ACSL4) metabolizes long-chain polyunsaturated fatty acids (PUFAs), enriching cell membranes with phospholipids susceptible to peroxidation and drive ferroptosis.
Virginie Poindessous, Helene Lazareth, Gilles Crambert, Lydie Cheval, Julio L. Sampaio, Nicolas Pallet   +5 more
doaj   +1 more source