Results 61 to 70 of about 145,713 (206)

What determines growth potential and juvenile quality of farmed fish species? [PDF]

open access: yes, 2013
Enhanced production of high quality and healthy fry is a key target for a successful and competitive expansion of the aquaculture industry. Although large quantities of fish larvae are produced, survival rates are often low or highly variable and growth ...
Alami-Durante   +225 more
core   +3 more sources

Single-cell transcriptome atlas of adult male and female human hookworm Ancylostoma ceylanicum

open access: yesiScience
Summary: Hookworms infect over 500 million people globally and are a major neglected tropical disease. Their high prevalence and reinfection rates, combined with emerging drug resistance, highlight the need for new therapeutic or vaccine targets.
Suman Bharti   +3 more
doaj   +1 more source

Preface [PDF]

open access: yes, 2007
n/
Bellomo, N., Maini, P. K.
core   +1 more source

A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq

open access: yesiScience
Summary: Understanding the cellular characteristics and regulatory networks of cells during the growth of human liver organoids is crucial for comprehending liver development and function.
Qinfeng Ma, Xu Zhang, Jianbo Pan
doaj   +1 more source

Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell-derived hepatic organoids

open access: yesiScience, 2023
Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses ...
Jong-Hwan Kim   +4 more
doaj   +1 more source

Systems biology and cancer, [Editorial] [PDF]

open access: yes, 2011
The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome,
Maini, Philip   +3 more
core   +2 more sources

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

open access: yesiScience
Summary: The application of single-cell technologies in clinical nephrology remains elusive. We generated an atlas of transcriptionally defined cell types and cell states of human kidney disease by integrating single-cell signatures reported in the ...
David Legouis   +15 more
doaj   +1 more source

Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation

open access: yesiScience, 2020
Summary: Although the dynamic features of type I coherent feedforward loop (C1-FFL) has been well studied, how C1-FFL shapes cell-to-cell heterogeneity remains unclear.
Jie Zhou   +4 more
doaj   +1 more source

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

open access: yes, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin   +60 more
core   +3 more sources

Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia

open access: yesiScience
Summary: Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway ...
Jacqueline E. Taudien   +22 more
doaj   +1 more source

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