Results 111 to 120 of about 388,340 (363)
Electrostatic Affinities and Binding Kinetics among $α_2\textrm{I}$ Integrin Domains, Divalent Cations and 21-mer Collagen Fragment [PDF]
arXiv, 2014 This paper compares simulation results and experimental published data concerning the interaction between $\alpha_2\beta_1$ integrin and collagen.This phenomenon is characterized by a competition among steric, reciprocal orientation constraints of the two structures and long range electrostatic force. The published experimental results shown that the $\
arxiv
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Identification of integrin drug targets for 17 solid tumor types. [PDF]
, 2018 Integrins are contributors to remodeling of the extracellular matrix and cell migration. Integrins participate in the assembly of the actin cytoskeleton, regulate growth factor signaling pathways, cell proliferation, and control cell motility.
Arun, Adith S +2 more
core +1 more source
16 kDa vasoinhibin binds to integrin alpha5 beta1 on endothelial cells to induce apoptosis
Endocrine Connections, 2018 Many functions of vasoinhibins have been reported, but its receptor has not been clarified yet. Vasoinhibins, 11–18 kDa N-terminal fragments of prolactin, have anti-angiogenic activity and act on endothelial cells to induce apoptosis and to inhibit ...
Kazunori Morohoshi +4 more
doaj +1 more source
Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration
Frontiers in Cell and Developmental Biology, 2020 The dynamic organization of actin cytoskeleton meshworks relies on multiple actin-binding proteins endowed with distinct actin-remodeling activities. Filamin A is a large multi-domain scaffolding protein that cross-links actin filaments with orthogonal ...
Isabelle Lamsoul +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities. [PDF]
, 2011 Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored.
Chi-Hung Lin +8 more
core +1 more source
Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX
Metabolites, 2018 Hypoxia is a prominent feature of the tumor microenvironment (TME) and cancer cells must dynamically adapt their metabolism to survive in these conditions. A major consequence of metabolic rewiring by cancer cells in hypoxia is the accumulation of acidic
Paul C. McDonald +2 more
doaj +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Model systems for studying cell adhesion and biomimetic actin networks
Beilstein Journal of Nanotechnology, 2014 Many cellular processes, such as migration, proliferation, wound healing and tumor progression are based on cell adhesion. Amongst different cell adhesion molecules, the integrin receptors play a very significant role.
Dorothea Brüggemann +2 more
doaj +1 more source