Results 231 to 240 of about 317,716 (343)

Relating conformation to function in integrin α5β1

Proceedings of the National Academy of Sciences of the United States of America, 2016
Yang Su, Wei Xia, Jing Li, T. Walz, M. Humphries, D. Vestweber, C. Cabañas, Chafen Lu, T. Springer   +8 more
semanticscholar   +1 more source

INTEGRIN ALPHA 10 FINELY REGULATES CARTILAGE MORPHOGENESIS AND MAINTENANCE [PDF]

Paolo Alberton, Xu‐Jia Wang, Christina Völcker, Verena Maier, Lutz Fleischhauer, Reinhild Hofmann, Heidrun Grondinger, Zsuzsanna Farkas, Maximilian Michael Saller, Evy Lundgren-Åkerlund, Hauke Clausen‐Schaumann, Attila Aszódi   +11 more
openalex   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

A cadherin-integrin-ECM code for presomitic mesoderm fluidity. [PDF]

Development
Genuth MA, Jülich D, Ton AT, Smith SJ, Guillon E, Shattuck MD, O'Hern CS, Holley SA.   +7 more
europepmc   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

GABA-independent activation of GABA_B receptor by mechanical forces. [PDF]

Nat Commun
Huo Y, Zhou Y, Lin L, Yang F, Meng J, He F, Zhang F, Song M, Shen C, Liu Y, Rondard P, Xu C, Shawn Xu XZ, Liu J.   +13 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
Long Y, Wang P, Lei J, Su B, Wei Q, Liu X.   +5 more
europepmc   +1 more source

The Rap1-RIAM-talin axis of integrin activation and blood cell function.

Blood, 2016
F. Lagarrigue, Chungho Kim, M. Ginsberg
semanticscholar   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source