Results 51 to 60 of about 388,340 (363)
Cell Reports, 2021 Summary: Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by macrophages and is a promising avenue in anti-cancer therapy.
Zhenghai Tang +6 more
doaj
eLife, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pirita Pekkonen +17 more
doaj +1 more source
A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
Frontiers in Molecular Biosciences, 2020 The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need.
Luciano Pirone +12 more
doaj +1 more source
Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement [PDF]
, 2021 The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes the contact and adhesion of cell to the extracellular matrix (ECM), while ECM signaling through integrin receptors also affects GTPase activity. We develop and investigate a
arxiv +1 more source
Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]
, 2011 Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Gloe, Torsten +4 more
core +1 more source
eLife, 2018 We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated.
Hannah J Green +3 more
doaj +1 more source
Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer
Frontiers in Genetics, 2020 Human integrin receptors are important for cell-cell and cell-matrix adhesion in normal epithelial cells. Emerging evidences have indicated integrin members are involved in cancer development and progression as well.
Anqi Wu +7 more
doaj +1 more source
A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation [PDF]
, 2011 Integrin signaling regulates cell migration and plays a pivotal role in developmental processes and cancer metastasis. Integrin signaling has been studied extensively and much data is available on pathway components and interactions. Yet the data is fragmented and an integrated model is missing.
arxiv +1 more source
PET/PDT theranostics: Synthesis and biological evaluation of a peptide-targeted gallium porphyrin [PDF]
, 2015 The development of novel theranostic agents is an important step in the pathway towards personalised medicine, with the combination of diagnostic and therapeutic modalities into a single treatment agent naturally lending itself to the optimisation and ...
Boyle, Ross W. +3 more
core +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source