Fibrillar adhesions are the primary integrin complexes shaped by matrix topography
Aaron J. Farrugia +14 more
openalex +1 more source
Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot +2 more
wiley +1 more source
Focal Adhesion and Cancer Cell Cycle-Associated Resistance. [PDF]
Ruksha TG +3 more
europepmc +1 more source
A novel form of integrin dysfunction involving beta 1, beta 2, and beta 3 integrins [PDF]
Hogg, N +6 more
core
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
The nonconserved integrin cytoplasmic region determines integrin subtype-specific characteristics by modulating talin1 binding kinetics. [PDF]
Kondo N +7 more
europepmc +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease. [PDF]
Cabañas C +6 more
europepmc +1 more source

