Results 221 to 230 of about 210,881 (328)

Integrins in Cardiovascular Health and Disease: Molecular Mechanisms and Therapeutic Opportunities. [PDF]

Biomolecules
Ławkowska K, Bonowicz K, Jerka D, Bai Y, Gagat M.   +4 more
europepmc   +1 more source

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

, 1991
Andrew L. Frelinger, Xiaoping Du, Edward F. Plow, Mark H. Ginsberg   +3 more
openalex   +1 more source

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo [PDF]

, 1992
Christopher J. Drake, Lynn Davis, Charles D. Little   +2 more
openalex   +1 more source

A machine learning-based investigation of integrin expression patterns in cancer and metastasis. [PDF]

Sci Rep
Shadman H, Gomrok S, Litle C, Cheng Q, Jiang Y, Huang X, Ziebarth JD, Wang Y.   +7 more
europepmc   +1 more source

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

Advanced Science, EarlyView.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis, Einollah Sarikhani, Vrund Patel, Dhivya Pushpa Meganathan, Leah Sadr, Anum Tahir, Zeinab Jahed, Padmini Rangamani   +7 more
wiley   +1 more source

Integrin-fibronectin interaction is a pivotal biological and clinical determinant in papillary thyroid carcinoma. [PDF]

Endocr Relat Cancer
Rocco D, Tortora A, Marotta V, Machado AM, Selistre-de-Araújo HS, Vitale M.   +5 more
europepmc   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. [PDF]

, 1994
Taichen Lin, Andrew D. Yurochko, Lori J. Kornberg, J. Steven Morris, J J Walker, Stephen Haskill, R. L. Juliano   +6 more
openalex   +1 more source

CYR61 as a Potential Biomarker and Target in Cancer Prognosis and Therapies. [PDF]

Cells
Schenker AJ, Ortiz-Hernández GL.
europepmc   +1 more source