Results 61 to 70 of about 8,633 (182)

Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase [PDF]

Journal of Bacteriology, 1992
Deletion of individual antibiotic resistance genes found within the variable region of integrons is demonstrated. Evidence for gene duplications and rearrangements resulting from the insertion of gene units at new locations is also presented. Deletion, duplication, and rearrangement occur only in the presence of the integron-encoded DNA integrase ...
C M, Collis, R M, Hall
openaire   +2 more sources

Antimicrobial resistance, class 1 integrons, and horizontal transfer in Salmonella isolated from retail food in Henan, China

Journal of Infection in Developing Countries, 2014
Introduction: Salmonellosis remains one of the most frequently occurring foodborne diseases worldwide, especially in developing countries. The increasing prevalence of multidrug resistance among Salmonella isolates from food has been an emerging problem ...
Tao Yu, Xiaojie Jiang, Qiaohong Zhou, Junmei Wu, Zhenbin Wu   +4 more
doaj   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Shuffling of DNA Cassettes in a Synthetic Integron [PDF]

, 2013
The complexity of even small gene networks makes them hardly amenable to rational design. Testing random combinations of genetic elements in a directed evolution procedure is thus of interest for many applications including metabolic engineering. Here we describe how the recombination machinery of class 1 integrons can be used to deliver and shuffle ...
Bikard, David, Mazel, Didier
openaire   +3 more sources

Molecular Characterization of Integrons in Acinetobacter baumannii : Description of a Hybrid Class 2 Integron [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT Twenty Acinetobacter baumannii strains resistant to various antibiotics were analyzed for integron content and sequences of the amplification products. Sixteen clinical isolates had a class 1 integron, 2 contained an additional class 1 or class 2 integron, but no class 3 integron was detected ...
M C, Ploy, F, Denis, P, Courvalin, T, Lambert   +3 more
openaire   +2 more sources

Antimicrobial resistance and integrons of ESBL-producing thermotolerant coliforms from a water reservoir in Tai'an, China

Journal of Infection in Developing Countries, 2017
Introduction: The contamination of water environments by extended-spectrum β-lactamases-producing thermotolerant coliforms (ESBL-TC) has aroused public concern.
Hongna Zhang, Xiaonan Zhao, Zhenzhen Zhai, Qing Li, Shuyuan Guo, Weishan Chang   +5 more
doaj   +1 more source

Dominant Role of Habitat Transformation in Driving the Divergence of Health‐Risk Related Microbial Functional Genes in Karst Mountain Parks: A Metagenomic Study

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This manuscript elucidates the impact of transforming karst mountain forests into urban parks on health‐risk related microbial functional genes and its implications for mitigating potential public health exposures. Distinctively, the study advances prior research by evaluating the variation in health‐related functional genes within parks of varying ...
Weize Wang, Chunhua Cen, Jingyi Yang
wiley   +1 more source

Antimicrobial profile of Salmonella enterica serotype Choleraesuis from free-range swine in Kakamega fish market, western Kenya

Journal of Infection in Developing Countries, 2014
Introduction: Salmonella enterica subspecies enterica serovar Choleraesuis is a host-adapted, facultative, intracellular pathogen that causes swine paratyphoid. Its antimicrobial resistance presents a challenge to feed manufacturing industries.
David M Onyango, Violet Mmbone Ndeda, Sarah A Wandili, Sifuna A Wawire, Phillip Ochieng   +4 more
doaj   +1 more source

Antimicrobial Resistance at the Human–Animal–Environment Interface: A One Health Perspective on Drivers, Transmission, and Public Health Responses

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Antimicrobial resistance (AMR) is a global health threat driven by interconnected antimicrobial use and environmental pressures across human, animal, and ecological systems. This review synthesizes current evidence on the major drivers, transmission pathways, reservoirs, surveillance challenges, and public health responses ...
Nurshad Ali
wiley   +1 more source

An evaluation of clonal relationship by PFGE method in Acinetobacter baumannii isolates, examining integron presence and antibiotic resistance

Journal of Infection in Developing Countries
Introduction: This study aims to investigate the presence of class 1, 2, and 3 integrons in Acinetobacter baumannii isolates, evaluate the relationship between integrons and antibiotic resistance and determine the clonal relationship between isolates by
Sedef Zeliha Öner, Hatice Er, Ahmet Çalışkan, Melek Demir, Hande Şenol, İlknur Kaleli   +5 more
doaj   +1 more source