Results 141 to 150 of about 765,675 (314)
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Actionable Wearables Data for the Neurology Clinic: A Proof‐of‐Concept Tool
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Wearable devices can monitor key health and fitness domains. In multiple sclerosis (MS), monitoring step count and sleep is feasible, valid, and offers a holistic glimpse of patient functioning and worsening. However, data generated from wearables are typically unavailable at the point of care.
Nicolette Miller +12 more
wiley +1 more source
The Effects of One versus Two Years of Intensive Reading Intervention Implemented with Late Elementary Struggling Readers. [PDF]
Learn Disabil Res Pract, 2018 Miciak J +6 more
europepmc +1 more source
MANGA COMICS AS APPEALING EXTENSIVE READING MATERIALS FOR THE TENTH GRADERS OF SENIOR HIGH SCHOOL [PDF]
, 2016 Manga comics are known as interesting reading materials for students in learning. Due to the fact that intensive reading in English teaching and learning has many problems especially dealing with limited class time and uninteresting materials, teachers
Anggraini, Paramita
core
Detecting rs‐fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Preserved resting‐state functional MRI (rs‐fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs‐fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice.
Jean Paul Medina Carrion +15 more
wiley +1 more source
Bringing Reading to Life. Tips for Vitalizing Reading in Primary School
RATE IssuesThis article explores the way in which reading can be brought to life in the English lessons starting from the roles of the teacher in intensive reading and going on with examples of activities through which we can bring reading to life. The roles of the
Ligia-Daniela Botiza
doaj