Results 101 to 110 of about 31,344,089 (309)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Genotype and injury severity modulate the effects of traumatic brain injury on sleep in Drosophila
microPublication BiologyTraumatic brain injuries (TBIs) have many negative impacts in humans (i.e. lifespan, cognitive function, sleep). Recently, Drosophila emerged as a model for studying these impacts in a controlled environment.
Leah Pisano, Michael P. Shahandeh
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
TEAD inhibitors re-sensitize drug-resistant NF1 MPNST cells to MEK inhibitors
microPublication BiologyNeurofibromatosis type 1 (NF1) patients develop non-malignant neurofibromas that can progress to Malignant Peripheral Nerve Sheath Tumors (MPNSTs). NF1 neurofibromas are treated with MEK inhibitors, such as mirdametinib and selumetinib, because they are ...
Yang Yang +4 more
doaj +1 more source
, 2010 The 2nd International Academic Forum for the Next Generation, The 4th ICIS International Forum, The 3rd ICIS International Symposium, Korean Studies Advancement Center and ICIS Cosponsored International Symposium, Some Thoughts on Bōnotsu, Conversation ...
4750 +1 more
core
An interaction landscape of ubiquitin signaling
, 2017 1, Source data of PLA assay to show the interaction of K6 polyubiquitin chain with CDKN2A and CDK7 in HeLa cells with doxorubicin stimulation.
zhang, X (via Mendeley Data) +2 more
core +1 more source
Teacher-student interaction and teachers' visual attention
, 2021 Data is really the result of teacher attention and teacher-student interaction in the classroom.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Shi, Y (via Mendeley Data), Shi, Yawen
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Spermatogenesis-specific Argonautes ALG-3/4 promote LEA-1 expression in oocytes
microPublication BiologySmall interfering RNAs bound to Argonautes ALG-3 and ALG-4 (ALG-3/4) in spermatocytes regulate fertility and aging in C. elegans. ALG-3/4 cell non-autonomously repress DAF-18/PTEN in the oocyte, thereby limiting the activity of DAF-16/FOXO and longevity.
Thomas Liontis, Alla Grishok
doaj +1 more source
, 2019 Raw data for two experiments for the paper "Distance Perception Warped by Social Structure: Social Interaction Information Compresses Distance ...
Jun Yin (94374) +5 more
core +1 more source