Results 251 to 260 of about 31,344,089 (309)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Correction: SLiMEnrich: computational assessment of protein-protein interaction data as a source of domain-motif interactions.

PeerJ, 2018
Idrees S, Pérez-Bercoff Å, Edwards RJ.
europepmc   +1 more source

Interactive Visualization of Cancer Data.

Journal of registry management
openaire   +1 more source

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The Data Interaction Game

Proceedings of the 2018 International Conference on Management of Data, 2018
As many users do not precisely know the structure and/or the content of databases, their queries do not exactly reflect their information needs. The database management systems (DBMS) may interact with users and leverage their feedback on the returned results to learn the information needs behind users' queries.
Ben McCamish, Vahid Ghadakchi, Arash Termehchy, Behrouz Touri, Liang Huang 0001   +4 more
openaire   +1 more source

Interactive data analysis

Computers & Industrial Engineering, 1976
Abstract Industrial Engineering no longer refers only to “production” type systems. New tools and techniques have been developed that allow the engineer to cross traditional disciplinary boundaries and solve problems that have otherwise been reserved for statisticians, economists, accountants, etc.
Herbert R. Ludwig, Joel M. Noe, Robert A. Chase   +2 more
openaire   +1 more source

Interacting with temporal data

CHI '09 Extended Abstracts on Human Factors in Computing Systems, 2009
Time serves as a basis for measuring the occurrence and evolution of natural phenomena, and governs the coordination of many of our everyday life activities. As the capacities of our digital tools have grown, they have begun to make readily available to us unprecedented quantities of new, rich, structured temporal information about the people and ...
Wendy E. Mackay, Max Van Kleek, Aurélien Tabard   +2 more
openaire   +1 more source

Interactive data analysis on numeric-data

Proceedings. IDEAS'99. International Database Engineering and Applications Symposium (Cat. No.PR00265), 2003
Data mining has been a hot topic in computer science. Many researchers have been putting lots of effort into how to extract explicit knowledge from large databases. Among the problems in data mining, finding useful patterns in large databases has attracted lots of interest in recent years.
Hong Ki Chu, Man Hon Wong 0001
openaire   +1 more source

Interaction Data Management

2011
Interaction data externalizes activities between an actor and an object, e.g. between a user and a computer system. The data is an important information source for user support and security applications. Nevertheless, generally little attention is given to interaction data.
Benedikt Schmidt 0001, Eicke Godehardt
openaire   +1 more source