Results 21 to 30 of about 59,170 (288)

Aqp2-Expressing Cells Give Rise to Renal Intercalated Cells [PDF]

Journal of the American Society of Nephrology, 2013
The mammalian collecting duct comprises principal and intercalated cells, which maintain sodium/water and acid/base balance, respectively, but the epigenetic contributors to the differentiation of these cell types remain unknown. Here, we investigated whether the histone H3 K79 methyltransferase Dot1l, which is highly expressed in principal cells ...
Hongyu, Wu, Lihe, Chen, Qiaoling, Zhou, Xi, Zhang, Stefan, Berger, Jiong, Bi, Dorothy E, Lewis, Yang, Xia, Wenzheng, Zhang   +8 more
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Cell intercalation in a simple epithelium [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
Cell intercalation is a key topological transformation driving tissue morphogenesis, homeostasis and diseases such as cancer cell invasion. In recent years, much work has been undertaken to better elucidate the fundamental mechanisms controlling intercalation.
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Novel Proinflammatory Function of Renal Intercalated Cells [PDF]

Annals of Nutrition and Metabolism, 2018
<b><i>Background:</i></b> Serious and often fatal acute kidney injury (AKI) is frequently seen after major surgery, local and remote organ damage, and sepsis. It is associated with uncontrolled inflammation, and is usually diagnosed only after the kidneys have gone through significant and often irreversible damage.
Sylvie, Breton, Dennis, Brown
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Single-cell transcriptomic analysis of the tumor ecosystem of adenoid cystic carcinoma

Frontiers in Oncology, 2022
Adenoid cystic carcinoma (ACC) is a malignant tumor that originates from exocrine gland epithelial cells. We profiled the transcriptomes of 49,948 cells from paracarcinoma and carcinoma tissues of three patients using single-cell RNA sequencing.
Quanquan Lin, Zhanjie Fang, Jinlong Sun, Fei Chen, Yipeng Ren, Zhenhong Fu, Sefei Yang, Lin Feng, Feng Wang, Zhigang Song, Wei Chen, Wenjun Yu, Chen Wang, Yixin Shi, Yue Liang, Haizhong Zhang, Hongzhu Qu, Xiangdong Fang, Qing Xi   +18 more
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Autoantibodies against intercalated cells in Sjögren's syndrome [PDF]

Kidney International, 2009
To the Editor: Recently, Bae et al. reported on a 43-year-old woman presenting with distal renal tubular acidosis (dRTA) associated with Sjogren’s syndrome. Confirming earlier reports, they showed decreased immunostaining for Hþ ATPase in the cortical collecting duct of the patient.
Devuyst, O, Lemaire, M, Mohebbi, N, Wagner, C A   +3 more
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Developmental Biology: Cell Intercalation One Step beyond [PDF]

Current Biology, 2008
Formation of the primitive streak, the equivalent of the blastopore, is a critical step during the early development of amniote embryos. Medio-lateral cell intercalation and the planar cell polarity pathway play a role during this earliest step of gastrulation in the chick embryo.
Bénazéraf, Bertrand, Pourquié, Olivier   +1 more
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Differentiation of renal beta-intercalated cells to alpha-intercalated and principal cells in culture. [PDF]

Proceedings of the National Academy of Sciences, 1992
The renal collecting duct is a heterogenous epithelium consisting of intercalated cells (ICC) and principal cells (PC). The origin of this cellular heterogeneity is not clear. To test the hypothesis that the two cell types might originate from one another, pure populations of ICC (beta subtype) and PC were isolated by fluorescence-activated cell ...
G, Fejes-Tóth, A, Náray-Fejes-Tóth
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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

eLife, 2017
Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively.
Max Werth, Kai M Schmidt-Ott, Thomas Leete, Andong Qiu, Christian Hinze, Melanie Viltard, Neal Paragas, Carrie J Shawber, Wenqiang Yu, Peter Lee, Xia Chen, Abby Sarkar, Weiyi Mu, Alexander Rittenberg, Chyuan-Sheng Lin, Jan Kitajewski, Qais Al-Awqati, Jonathan Barasch   +17 more
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Proliferation of acid-secretory cells in the kidney during adaptive remodelling of the collecting duct. [PDF]

PLoS ONE, 2011
The renal collecting duct adapts to changes in acid-base metabolism by remodelling and altering the relative number of acid or alkali secreting cells, a phenomenon termed plasticity.
Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A Wagner   +3 more
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Collecting Duct Intercalated Cell Function and Regulation [PDF]

Clinical Journal of the American Society of Nephrology, 2015
Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption ...
Ankita, Roy, Mohammad M, Al-bataineh, Núria M, Pastor-Soler   +2 more
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