Results 51 to 60 of about 162,554 (298)

ATP Release from Cultured Endothelial Cells and Intercellular Calcium Signaling during Shear Stress Exposure

Journal of Biomechanical Science and Engineering, 2009
Intracellular calcium ([Ca2+]i) is a second messenger molecule critical for numerous intracellular signaling pathways in endothelial cells (ECs). Direct mechanical stimulation imposed on single ECs by a microprobe has been demonstrated to increase [Ca2 ...
Susumu KUDO, Kaoru HOSOE, Makoto HOSOBUCHI, Naoto KAWASAKI, Kazuo TANISHITA   +4 more
doaj   +1 more source

TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma

Cell Death and Disease
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation.
Donghee Kang, Hyun Jung Hwang, Yurim Baek, Jee Young Sung, KyeongJin Kim, Heon Joo Park, Young-Gyu Ko, Yong-Nyun Kim, Jae-Seon Lee   +8 more
doaj   +1 more source

Roles of connexins and pannexins in (neuro)endocrine physiology. [PDF]

, 2015
International audienceTo ensure appropriate secretion in response to organismal demand, (neuro)endocrine tissues liberate massive quantities of hormone, which act to coordinate and synchronize biological signals in distant secretory and non-secretory ...
Desarménien, MG, Guérineau, NC, Hodson, DJ, Legros, C   +3 more
core   +5 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges?

Cell Stress, 2020
Intercellular communication is a fundamental property of multicellular organisms, necessary for their adequate responses to changing environment. Tunneling nanotubes (TNTs) represent a novel means of intercellular communication being a long cell-to-cell ...
Olga Korenkova, Anna Pepe, Chiara Zurzolo   +2 more
doaj   +1 more source

Single-cell transcriptome reveals cellular heterogeneity and lineage-specific regulatory changes of fibroblasts in post-traumatic urethral stricture

Biochemistry and Biophysics Reports, 2023
Fibroblast is the critical repair cell for urethral wound healing. The dysfunction of fibroblasts can lead to excessive fibrosis and hypertrophic scar, which eventually leads to post-traumatic urethral stricture. However, the fibroblast subpopulation and
Kuiqing Li, Cong Lai, Shangyan Hei, Cheng Liu, Zhuohang Li, Xu Kewei   +5 more
doaj   +1 more source

Stability of Intercelular Exchange of Biochemical Substances Affected by Variability of Environmental Parameters

, 2010
Communication between cells is realized by exchange of biochemical substances. Due to internal organization of living systems and variability of external parameters, the exchange is heavily influenced by perturbations of various parameters at almost all ...
ANJA MIHAILOVIĆ, Devaney R. L., DRAGUTIN T. MIHAILOVIĆ, Grenfall B. T., IGOR BALAŽ, Kitano H., Longo D., MIRKO BUDINČEVIĆ, Pikovsky A.   +8 more
core   +1 more source

Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions [PDF]

, 2012
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling.
Andrew C Oates, Koichiro Uriu, Luis G Morelli, Oates A C, Peruani F, Saúl Ares   +5 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source