Results 21 to 30 of about 80,758 (214)

Strategies to increase drug penetration in solid tumors

Frontiers in Oncology, 2013
Despite significant improvement in modalities for treatment of cancer that led to a longer survival period, the death rate of patients with solid tumors has not changed during the last decades.
Il-Kyu eChoi, Robert eStrauss, Maximilian eRichter, Chae-Ok eYun, Andre eLieber   +4 more
doaj   +1 more source

In silico analyses of conservational, functional and phylogenetic distribution of the LuxI and LuxR homologs in Gram-positive bacteria

Scientific Reports, 2017
LuxI and LuxR are key factors that drive quorum sensing (QS) in bacteria through secretion and perception of the signaling molecules e.g. N-Acyl homoserine lactones (AHLs).
Akanksha Rajput, Manoj Kumar
doaj   +1 more source

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain [PDF]

, 2015
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors ...
Bultynck, Geert, De Smedt, Humbert, Decrock, Elke, Ivanova, Hristina, Kasri, Nael Nadif, Lemmens, Irma, Leybaert, Luc, Martens, Lennart, Missiaen, Ludwig, Monaco, Giovanni, Parys, Jan B, Sorrentino, Vincenzo, Tavernier, Jan, Vandermarliere, Elien, Vervliet, Tim   +14 more
core   +1 more source

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus [PDF]

, 1999
Synaptic NMDA-type glutamate receptors are anchored to the second of three PDZ (PSD-95/Discs large/ZO-1) domains in the postsynaptic density (PSD) protein PSD-95.
Apperson, Michelle, Kennedy, Mary B., Vazquez, Luis, Zhang, Wandong   +3 more
core   +1 more source

Expressions of Transforming Growth Factor β1 Signaling Cytokines in Aortic Dissection

Brazilian Journal of Cardiovascular Surgery
Objective: To demonstrate the underlying mechanisms of aortic dissection compared to those of coronary artery disease in terms of the transforming growth factor-beta (TGF-β) signaling pathway.
Shi-Min Yuan, Hong Lin
doaj   +1 more source

Leaf development: A cellular perspective

Frontiers in Plant Science, 2014
Through its photosynthetic capacity the leaf provides the basis for growth of the whole plant. In order to improve crops for higher productivity and resistance for future climate scenarios, it is important to obtain a mechanistic understanding of leaf ...
Gerrit TS Beemster, Shweta eKalve, Dirk eDe Vos, Dirk eDe Vos   +3 more
doaj   +1 more source

Regulation of gap junction function; the role of nitric oxide. [PDF]

, 2013
Myocardial ischemia resulting from sudden occlusion of a coronary artery is one of the major causes in the appearance of severe, often life-threatening ventricular arrhythmias.
Gönczi, Márton, Kovács, Mária, Miskolczi, Gottfried, Végh, Ágnes   +3 more
core   +2 more sources

Topical application of bFGF on acid-conditioned and non-conditioned dentin: effect on cell proliferation and gene expression in cells relevant for periodontal regeneration

Journal of Applied Oral Science
Periodontal regeneration is still a challenge in terms of predictability and magnitude of effect. In this study we assess the biological effects of combining chemical root conditioning and biological mediators on three relevant cell types for periodontal
Fernanda Regina Godoy Rocha, João Antônio Chaves de Souza, Morgana Rodrigues Guimarães-Stabili, José Eduardo Cezar Sampaio, Carlos Rossa Junior   +4 more
doaj   +1 more source

Mechanisms of action of formononetin, an extract from Astragalus membranaceus medicinal plant, in ameliorating Alzheimer’s disease [PDF]

Exploration of Neuroscience
Alzheimer’s disease (AD), the term “dementia”, describes a specific neuropathology together with the development and progression of age-related cognitive and functional loss.
Manpreet Kaur, Shivangi Singh, Avikramjeet Singh, Anish Singh   +3 more
doaj   +1 more source

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]

, 2014
Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Bultynck, Geert, D'hondt, Catheleyne, Himpens, Bernard, Iyyathurai, Jegan, Leybaert, Luc   +4 more
core   +2 more sources