Results 41 to 50 of about 886,416 (237)
Cas clinique : Un homme de 86 ans est retrouvé inconscient à son domicile sans notion d’intoxication. À son admission, il présente une acidose (pH = 7,24) associée à une hyperlactacidémie à 26 mmol/L sur ABL 825® Radiometer,
Mustapha Moulsma +4 more
core +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The Standard Model Effective Field Theory (SMEFT) offers a powerful theoretical framework for parameterizing the low-energy effects of heavy new particles with masses far above the scale of electroweak symmetry breaking.
Anne Mareike Galda +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Space-Power Adaptive Interference Steering to Manage Interference in XIC
With the rapid development of wireless communication technologies, interference has become a key impediment in the improvement of network capacity. In practice, although dense deployment of network can effectively increase the spectrum efficiency, severe
Zhao Li +4 more
doaj +1 more source
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
International audience-Dans cet article, nous nous intéressons au comportement d'un système full-duplex (FD) multiple input multiple output (MIMO) pour deux modélisations du canal d'auto-interférence (SI pour self-interference) inhérent au FD : le modèle
Savelli, Patrick +4 more
core +1 more source
En dosant les hydrocarbures aliphatiques contenus dans l'eau au moyen de leur absorption dans l'infra-rouge à 2900 cm-1 (zone d'absorption des groupes -CH2-), on a constaté une interférence due aux acides gras, qui absorbent le plus à 1700 cm-1 (zone d ...
Renée Chambon-Mougenot, Paul Chambon
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Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source

