Results 61 to 70 of about 886,416 (237)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Effet de l'âge sur les capacités d'inhibition d'une interférence de type Stroop
, 1995 Coulon N., Comblez V., Lamerand H., Toe P. Effet de l'âge sur les capacités d'inhibition d'une interférence de type Stroop. In: Bulletin de psychologie, tome 49 n°422, 1995. Colloque « Effets de l'âge et processus mentaux ». pp.
Comblez, V. +3 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Annulation de l'Auto-interférence dans un Système MIMO Full-Duplex par un Précodage MMSE Contraint
International audienceCet article présente une nouvelle méthode de précodage basée sur l'annulation de l'auto-interférence (SIC) dans le domaine spatial, appelée MMSE contraint (C-MMSE), pour un système massive MIMO en full-duplex (FD) sous-dimensionné ...
Chen, Xuan +2 more
core +1 more source
Diboson interference resurrection
Physics Letters B, 2018 High-energy diboson processes at the LHC are potentially powerful indirect probes of heavy new physics, whose effects can be encapsulated in higher-dimensional operators or in modified Standard Model couplings.
Giuliano Panico +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2015 International audienceAu sein du modèle théorique de la médiation, la notion d' "interférence des plans" semble entrer en contradiction avec le principe dit de "réciprocité des faces", supposant une clôture de chaque plan sur lui-même.
Morvan, Malo
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