Results 81 to 90 of about 925,963 (223)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Interference across time: dissociating short from long temporal interference

Frontiers in Psychology
Our ability to identify an object is often impaired by the presence of preceding and/or succeeding task-irrelevant items. Understanding this temporal interference is critical for any theoretical account of interference across time and for minimizing its ...
Ilanit Hochmitz, Ahmad Abu-Akel, Ahmad Abu-Akel, Yaffa Yeshurun, Yaffa Yeshurun   +4 more
doaj   +1 more source

Topographies of Interference

Lateral, 2014
'Topographies of Interference' is meant to provoke viewers into thinking about information services’ material presence in the world, and to relocate the vision of large tech companies as primarily urban centers to one that highlights their presence in ...
Jocelyn Monahan, Jeff Curran
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Effet de l'âge sur les capacités d'inhibition d'une interférence de type Stroop

, 1995
Coulon N., Comblez V., Lamerand H., Toe P. Effet de l'âge sur les capacités d'inhibition d'une interférence de type Stroop. In: Bulletin de psychologie, tome 49 n°422, 1995. Colloque « Effets de l'âge et processus mentaux ». pp.
Comblez, V., Toe, P., Lamerand, H., Coulon, N.   +3 more
core  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Interference alignment based secure transmission scheme in multi-user interference networks

物联网学报, 2023
Faced with the requirement of information security in internet of things, a scenario of multi-user interference networks with multiple eavesdroppers was considered, and an interference alignment (IA) scheme based physical layer secure transmission was ...
Lin HU, Jiabing FAN, Hong WEN, Jie TANG, Qianbin CHEN   +4 more
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source