Results 71 to 80 of about 877,216 (239)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Diboson interference resurrection

Physics Letters B, 2018
High-energy diboson processes at the LHC are potentially powerful indirect probes of heavy new physics, whose effects can be encapsulated in higher-dimensional operators or in modified Standard Model couplings.
Giuliano Panico, Francesco Riva, Andrea Wulzer   +2 more
doaj   +1 more source

Aider l'élève à comprendre le fonctionnement de la physique et son articulation avec la vie quotidienne [PDF]

, 2004
National audienceCet article est une réflexion issue du travail d'un groupe de recherche-développement de l'académie de Lyon (groupe « Outils »), soutenu et financé par l'INRP (Institut national de recherche pédagogique) et ayant réuni pendant trois ans,
Pierre, Gaidioz, Tiberghien, Andrée, Vince, Jacques   +2 more
core   +2 more sources

Différenciation sexuelle des interprétations causales de la maladie en Afrique subsaharienne (Burkina Faso) [PDF]

, 2004
Le sexe social intervient dans la construction de la représentation de plusieurs maladies chez les Mossi du Burkina Faso, en particulier celles qui concernent la sexualité (maladies transmises lors d'un rapport sexuel), la reproduction individuelle ...
Egrot, Marc
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Labor Relations Boards and the Courts [PDF]

, 1966
INTRODUCTION« Le Conseil canadien des relations ouvrières » et la plupart de nos Commissions provinciales possèdent une compétence exclusive dans les cas qui leur sont soumis, en vertu de textes restrictifs de l'intervention judiciaire (privative clauses)
Weatherhill, J. F. W.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Linear Space-Time Interference Alignment for $K$ -User MIMO Interference Channels

IEEE Access, 2018
Interference is believed to be the most significant bottleneck for the next-generation wireless networks to achieve high throughout. Interference alignment (IA), as a novel interference management scheme to break through the traditional interference ...
Xiaorong Jing, Linlin Mo, Hongqing Liu, Cuicui Zhang   +3 more
doaj   +1 more source