Results 71 to 80 of about 377,510 (268)

Impact of Resistivity on Electrical Characteristics of Al-Doped ZnO/p Si Heterostructures

East European Journal of Physics
This study investigates the impact of the resistivity of Aluminum-doped Zinc Oxide (AZO) films on the electrical characteristics of AZO/p-Si heterojunctions.
Fakhriddin T. Yusupov, Mekhriddin F. Akhmadjonov, Dadakhon Sh. Khidirov, Dilmuhammad Kh. Tolaboyev, Ikhtiyor M. Tursunov   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Impact of Defects on the Low-Field Electron Mobility in GaN-on-Si HEMTs

IEEE Journal of the Electron Devices Society
In this work, we investigate the field and temperature dependence of the electron mobility in aluminum-gallium-nitride/gallium-nitride (AlGaN/GaN) high electron mobility transistors (HEMTs) realized on GaN-on-silicon (Si) substrates.
Ran Zhou, D. J. Gravesteijn, R. J. E. Hueting   +2 more
doaj   +1 more source

High-speed electro-optic modulation in topological interface states of a one-dimensional lattice. [PDF]

Light Sci Appl, 2023
Zhang Y, Shen J, Li J, Wang H, Feng C, Zhang L, Sun L, Xu J, Liu M, Wang Y, Tian Y, Dong J, Su Y.   +12 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Micro-Reflector Integrated Multichannel μLED Optogenetic Neurostimulator With Enhanced Intensity

Frontiers in Mechanical Engineering, 2018
This paper reports the fabrication and characterization of an optical neuro-stimulator array that consists of 32-channel microscale light-emitting diodes (μ-LEDs) coupled with microscale reflectors for intensity enhancement.
Wasif Khan, Monica Setien, Erin Purcell, Erin Purcell, Wen Li   +4 more
doaj   +1 more source

The luminescence mechanism of ligand-induced interface states in silicon quantum dots. [PDF]

Nanoscale Adv, 2023
Zhou J, Ma F, Chen K, Zhao W, Yang R, Qiao C, Shen H, Su WS, Lu M, Zheng Y, Zhang R, Chen L, Wang S.   +12 more
europepmc   +1 more source