Results 1 to 10 of about 779,562 (365)
Frontiers in Immunology, 2021 ObjectivesType I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical ...
Helena Enocsson +8 more
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Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense
Frontiers in Cell and Developmental Biology, 2021 Interferon (IFN) is a crucial first line of defense against viral infection. This cytokine induces the expression of several IFN-Stimulated Genes (ISGs), some of which act as restriction factors.
Mounira K. Chelbi-Alix +2 more
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Journal of Veterinary Research, 2021 Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang +8 more
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Frontiers in Immunology, 2021 Macrophages (MΦ) are known to exhibit distinct responses to viral and bacterial infection, but how they react when exposed to the pathogens in succession is less well understood.
Erik Schilling +7 more
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Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents
Journal of Veterinary Research, 2021 Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang +8 more
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DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling
Frontiers in Cell and Developmental Biology, 2022 DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses.
Rong Shen +6 more
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mBio, 2021 Outbreaks of emerging viral pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a major medical challenge. There is a pressing need for antivirals that can be rapidly deployed to curb infection and dissemination. We determined
Sook-Young Sohn +10 more
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Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
Virulence, 2021 The Interferon (IFN) response is crucial to restrain pathogenic infections. Investigations into flavivirus-host interactions reported that the high virulence is linked to innate immune evasion.
Elisa Fanunza +9 more
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The Interplay between the Host Microbiome and Pathogenic Viral Infections
mBio, 2021 The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by ...
Rubén González, Santiago F. Elena
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Evolution of Interferons and Interferon Receptors [PDF]
Frontiers in Immunology, 2017 The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
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