Results 1 to 10 of about 1,191,146 (396)
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
Emerging Microbes and Infections, 2020 The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infections worldwide (
Chun-Kit Yuen, Xiaohui Wang, Hin Chu
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Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
Frontiers in Immunology, 2018 Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases ...
Flávia Castro +2 more
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Mechanisms of type-I- and type-II-interferon-mediated signalling
Nature Reviews Immunology, 2005 Leonidas C Platanias
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Journal of Veterinary Research, 2021 Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang +8 more
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Frontiers in Immunology, 2022 Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem +10 more
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Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents
Journal of Veterinary Research, 2021 Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang +8 more
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Science, 2020 Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
J. Hadjadj +29 more
semanticscholar +1 more source
The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]
, 2014 The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller +36 more
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Nature Communications, 2020 Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012.
T. Sheahan +18 more
semanticscholar +1 more source
Evolution of Interferons and Interferon Receptors [PDF]
Frontiers in Immunology, 2017 The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
openaire +4 more sources