Results 1 to 10 of about 574,262 (313)

Antivirals against HCV infection: the story thus far

Journal of Infection in Developing Countries, 2022
Remarkable scientific breakthroughs have been made in the stride towards the development of potent and tolerable hepatitis C regimens within the last three decades.
Ahmad Adebayo Irekeola, Engku Nur Syafirah EAR, Nur Amalin Zahirah Mohd Amin, Nazri Mustaffa, Rafidah Hanim Shueb   +4 more
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Expression, purification, and bioactivity of a soluble recombinant ovine interferon-tau in Escherichia coli

Journal of Veterinary Research, 2021
Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
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Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents

Journal of Veterinary Research, 2021
Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense

Biomolecules & Biomedicine, 2021
Coronavirus disease-19 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has become a major global health concern.
Abualgasim Elgaili Abdalla , Jianping Xie, Kashaf Junaid, Sonia Younas, Tilal Elsaman, Khalid Omer Abdalla Abosalif, Ayman Ali Mohammed Alameen, Mahjoob Osman Mahjoob, Mohammed Yagoub Mohammed Elamir, Hasan Ejaz   +9 more
doaj   +1 more source

Grass Carp Reovirus VP35 Degrades MAVS Through the Autophagy Pathway to Inhibit Fish Interferon Production

Frontiers in Immunology, 2021
Fish interferon (IFN) is a crucial cytokine for a host to resist external pathogens, conferring cells with antiviral capacity. Meanwhile, grass carp reovirus (GCRV) is a strong pathogen that causes high mortality in grass carp. Therefore, it is necessary
Long-Feng Lu, Can Zhang, Can Zhang, Zhuo-Cong Li, Zhuo-Cong Li, Xiao-Yu Zhou, Xiao-Yu Zhou, Jing-Yu Jiang, Jing-Yu Jiang, Dandan Chen, Yong-An Zhang, Yong-An Zhang, Shun Li   +12 more
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DEAD-Box RNA Helicase 21 (DDX21) Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus via Multiple Mechanisms

Viruses, 2022
The porcine reproductive and respiratory syndrome virus (PRRSV) remains a persistent hazard in the global pig industry. DEAD (Glu-Asp-Ala-Glu) box helicase 21 (DDX21) is a member of the DDX family.
Jia Li, Dang Wang, Puxian Fang, Yu Pang, Yanrong Zhou, Liurong Fang, Shaobo Xiao   +6 more
doaj   +1 more source

Pharmacotherapy of hepatitis D: the current and the future [PDF]

Exploration of Digestive Diseases
Hepatitis D virus (HDV), a satellite virus requiring hepatitis B surface antigen (HBsAg) for propagation, is a hepatotropic virus implicated in acute and chronic viral hepatitis, with an accentuated risk of cirrhosis and hepatocellular carcinoma.
George Sarin Zacharia, Anu Jacob
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Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

Viruses, 2022
The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive.
Dang Wang, Ruixue Wang, Kui Li
doaj   +1 more source

Immunological Effects of Cold Atmospheric Plasma-Treated Cells in Comparison with Those of Cells Treated with Lactaptin-Based Anticancer Drugs

Biophysica, 2022
The ability of dying cancer cells to induce an anticancer immune response can increase the effectiveness of anticancer therapies, and such type of death is termed immunogenic cell death (ICD).
Olga Troitskaya, Diana Novak, Mikhail Varlamov, Mikhail Biryukov, Anna Nushtaeva, Galina Kochneva, Dmitriy Zakrevsky, Irina Schweigert, Vladimir Richter, Olga Koval   +9 more
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The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Gastroenterology Insights, 2022
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases.
Chunye Zhang, Shuai Liu, Ming Yang
doaj   +1 more source