Results 1 to 10 of about 132,342 (218)

Double-edged effects of interferons on the regulation of cancer-immunity cycle [PDF]

OncoImmunology, 2021
Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types.
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Xiaobo Li   +7 more
doaj   +2 more sources

Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

Viruses, 2022
The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive.
Dang Wang, Ruixue Wang, Kui Li
doaj   +1 more source

Immunological Effects of Cold Atmospheric Plasma-Treated Cells in Comparison with Those of Cells Treated with Lactaptin-Based Anticancer Drugs

Biophysica, 2022
The ability of dying cancer cells to induce an anticancer immune response can increase the effectiveness of anticancer therapies, and such type of death is termed immunogenic cell death (ICD).
Olga Troitskaya, Diana Novak, Mikhail Varlamov, Mikhail Biryukov, Anna Nushtaeva, Galina Kochneva, Dmitriy Zakrevsky, Irina Schweigert, Vladimir Richter, Olga Koval   +9 more
doaj   +1 more source

Expression, purification, and bioactivity of a soluble recombinant ovine interferon-tau in Escherichia coli

Journal of Veterinary Research, 2021
Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Gastroenterology Insights, 2022
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases.
Chunye Zhang, Shuai Liu, Ming Yang
doaj   +1 more source

Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents

Journal of Veterinary Research, 2021
Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Frontiers in Immunology, 2022
Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem, Mustafa H. Ghanem, Andrew J. Shih, Houman Khalili, Emily G. Werth, Jayanta K. Chakrabarty, Lewis M. Brown, Kim R. Simpfendorfer, Kim R. Simpfendorfer, Peter K. Gregersen, Peter K. Gregersen   +10 more
doaj   +1 more source

Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection

Cell Reports Medicine, 2020
Summary: Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment and prevention. Previously, we found that topical rectal tenofovir gel caused immunological changes in the mucosa.
Sean M. Hughes, Claire N. Levy, Fernanda L. Calienes, Joanne D. Stekler, Urvashi Pandey, Lucia Vojtech, Alicia R. Berard, Kenzie Birse, Laura Noël-Romas, Brian Richardson, Jackelyn B. Golden, Michael Cartwright, Ann C. Collier, Claire E. Stevens, Marcel E. Curlin, Timothy H. Holtz, Nelly Mugo, Elizabeth Irungu, Elly Katabira, Timothy Muwonge, Javier R. Lama, Jared M. Baeten, Adam Burgener, Jairam R. Lingappa, M. Juliana McElrath, Romel Mackelprang, Ian McGowan, Ross D. Cranston, Mark J. Cameron, Florian Hladik   +29 more
doaj   +1 more source

Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection

Frontiers in Immunology, 2016
The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using
Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Naoki Yamamoto, Edin J Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi, Hiroyuki Oshiumi   +11 more
doaj   +1 more source

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

Frontiers in Microbiology, 2020
The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection.
A. Cristina Gonzalez-Perez, Markus Stempel, Markus Stempel, Baca Chan, Melanie M. Brinkmann, Melanie M. Brinkmann   +5 more
doaj   +1 more source