Results 11 to 20 of about 236,190 (268)

Prevention of lethal respiratory vaccinia infections in mice with interferon-α and interferon-γ [PDF]

open access: yesFEMS Immunology & Medical Microbiology, 2004
The antiviral efficacy of interferons (IFNs) was evaluated using a vaccinia intranasal infection model in mice in this study. We provide evidence that intranasal administration of IFN-alpha and IFN-gamma (days -1 to +3) resulted in 100 and 90% survival against a lethal respiratory vaccinia infection (8 LD50) in mice, respectively; whereas no animals in
Ge, Liu   +10 more
openaire   +2 more sources

Expression of VWF and Interferon γ in renal allograft biopsies and correlation with inflammatory cells; Single center experience

open access: yesJournal of Contemporary Medical Sciences, 2021
Objective: Gene expression profiling by microarrays or RT PCR had been studied in certain western centers to enhance the diagnostic accuracy of allograft biopsy, however, such sophisticated tests are difficult to apply in developing countries. This study was conducted to evaluate the expression of von Willebrand factor (VWF) and Interferon-gamma (IFNγ)
Alaa Abbas Ali   +2 more
openaire   +2 more sources

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

open access: yesmBio, 2020
The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-γ) is the major cytokine involved in
Jaya Bhushan   +6 more
doaj   +1 more source

Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2016
Buruli ulcer (BU), caused by infection with Mycobacterium ulcerans, is a chronic necrotizing human skin disease associated with the production of the cytotoxic macrolide exotoxin mycolactone.
Raphael Bieri   +3 more
doaj   +1 more source

Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation

open access: yesJournal of Health Science and Medical Research (JHSMR), 2023
Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine pathway regulating Mycobacterium tuberculosis infection.
Neha Gupta   +3 more
doaj   +1 more source

LEVELS OF IL-4 AND Γ- INTERFERON IN CHILDREN’S BLOOD SERUM AS PREDICTORS OF ASTHMA FORMATION

open access: yesНеонатологія, хірургія та перинатальна медицина, 2023
Introduction. The prevalence of asthma continues to increase every year. Asthma is the leading chronic disease. Infl ammation, both acute and chronic, is closely related to the action of cytokines (pro- and anti-infl ammatory).
Н. Макєєва   +4 more
doaj   +1 more source

B Cells and Programmed Death-Ligand 2 Signaling Are Required for Maximal Interferon-γ Recall Response by Splenic CD4⁺ Memory T Cells of Mice Vaccinated with Mycobacterium tuberculosis Ag85B.

open access: yesPLoS ONE, 2015
CD4+ T cells producing interferon-γ are crucial for protection against Mycobacterium tuberculosis infection and are the cornerstone of tuberculosis vaccination and immunological diagnostic assays.
Antonella Riccomi, Carla Palma
doaj   +1 more source

Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-γ in Chinese Sturgeon Macrophages

open access: yesFrontiers in Immunology, 2022
To further study the biological function of interferon-gamma (IFN-γ) in the Chinese sturgeon (Acipenser sinensis), we conducted a transcriptome analysis of primary macrophages induced by IFN-γ using Illumina sequencing technology.
Guangyi Ding   +9 more
doaj   +1 more source

12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation

open access: yesMediators of Inflammation, 2010
Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types.
Alexa R. Lindley   +3 more
doaj   +1 more source

Interferon-β induction byChlamydia pneumoniaein human smooth muscle cells [PDF]

open access: yesFEMS Immunology & Medical Microbiology, 2001
Clinical studies have suggested a causal or contributory role of Chlamydia pneumoniae infection in asthma and atherosclerosis. The activation of synthetic functions of smooth muscle cells (SMC) including the production of cytokines and growth factors plays a major role in the formation of fibrous atherosclerotic plaques as well as in structural ...
J, Rödel   +6 more
openaire   +2 more sources

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