Results 121 to 130 of about 55,486 (297)

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Identifying predictors of interferon-gamma release assay results in pediatric latent tuberculosis: a protective role of BCG?

, 2012
Rationale: Interferon-gamma release assays are widely used to diagnose latent infection with Mycobacterium tuberculosis in adults, but their performance in children remains incompletely evaluated to date.
Kampmann, Beate, Tsolia, Maria, Basu Roy, Robindra, Ruga, Ezia, Velizarova, Svetlana, Altet Gómez, Neus, Sotgiu, Giovanni   +6 more
core  

KORELASI ANTARA INTERFERON GAMMA RELEASE ASSAY METODE ELISPOT DAN JUMLAH SEL LIMFOSIT T CD4+ PADA PENDERITA HIV POSITIF [PDF]

, 2018
Pendahuluan. HIV adalah virus yang dapat menyebabkan AIDS, yang berpengaruh pada sistem kekebalan tubuh dan melemahkan fungsi tubuh dalam melawan penyakit. Sel primer yang diserang HIV adalah limfosit T CD4+. Infeksi Oportunistik (IO) merupakan faktor
Nabil Salim Ambar, NIM011328156304
core  

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

The evaluation of Mycobacterium tuberculosis complex species-specific antigens and purified protein derivatives for the detection of bovine tuberculosis using the interferon-gamma release assay

, 2013
Mycobacterium bovis is the causative agent of tuberculosis in cattle and the most common organism isolated from cattle with tuberculosis. The broad host range, low infective dose, and presence of wildlife reservoirs make eradication and control of bovine
Bass, Kristin
core   +1 more source

Interferon-gamma release assay performance of pleural fluid and peripheral blood in pleural tuberculosis.

, 2013
BACKGROUND: The diagnosis of pleural tuberculosis (TB) remains to be difficult. Interferon-gamma release assay (IGRA) is a promising method for diagnosing TB in low TB burden countries.
Mengqiu Gao, Xinting Yang, Xia Zhang, Fengjiao Du, Xiaoguang Wu, Zongde Zhang, Liping Ma, Li Xie, Fei Liu, Zitong Wang, Hongyan Jia, Liqun Zhang   +11 more
core   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

«Interferon Gamma Release Assays» oder IGRA

Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2021
Minh Khoa Truong, Laurent Nicod, Jesica Mazza-Stalder, Vincent Aubert, Peter Vollenweider   +4 more
openaire   +1 more source