Results 101 to 110 of about 55,486 (297)

A retrospective cohort study of patients treated with anti-tuberculous therapy for presumed ocular tuberculosis

Journal of Ophthalmic Inflammation and Infection, 2017
Background Uveitis involving the posterior segment is a significant and potentially blinding condition. The diagnosis and treatment of patients with uveitis associated with tuberculosis remains controversial, and commonly, patients are systemically well.
Erika Marie Damato, Sarah Dawson, Xiaoxuan Liu, Chandoshi Mukherjee, John Horsburgh, Alastair K. Denniston, Edward Moran, Martin Dedicoat, Philip Ian Murray   +8 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Kaplan-Meier curve to development of active tuberculosis disease by composite risk factor combining high HIV viral load of greater than 100,000 copies per mL, CD4 cell count and interferon-gamma release assay (IGRA)(N = 772).

, 2015
Kaplan-Meier curve to development of active tuberculosis disease by composite risk factor combining high HIV viral load of greater than 100,000 copies per mL, CD4 cell count and interferon-gamma release assay (IGRA)(N = 772).
Hsi-Hsun Lin (473561), Kuan-Sheng Wu (784205), Hsin-Yun Sun (61134), Jui-Kuang Chen (784206), Susan Shin-Jung Lee (784202), Chien-Chin Hung (784203), Ih-Jen Su (87501), Chi-Tai Fang (125570), Chin-Hui Yang (450823), Hung-Chin Tsai (673178), Yao-Shen Chen (139714), Cheng-Len Sy (784204)   +11 more
core   +1 more source

Performance of Interferon-γ Release Assays in Patients with Mycobacterium kansasii Infection

Infection and Drug Resistance, 2022
Chun-Hai Gao,1 Yan-An Zhang,2,3 Mao-Shui Wang3– 5 1Department of Clinical Laboratory, Linyi People’s Hospital, Linyi, People’s Republic of China; 2Department of Cardiovascular Surgery, Shandong Public Health Clinical Center, Cheeloo College of Medicine ...
Gao CH, Zhang YA, Wang MS
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Tuberculin skin test (TST) and interferon gamma release assay (IGRA) in household contacts according to the number of colony-forming units of M. tuberculosis in cough-generated aerosols and sputum acid-fast bacilli smear microscopy results.

, 2018
Tuberculin skin test (TST) and interferon gamma release assay (IGRA) in household contacts according to the number of colony-forming units of M. tuberculosis in cough-generated aerosols and sputum acid-fast bacilli smear microscopy results.
Patricia Marques-Rodrigues (591520), Laura F. White (298306), Carlos Acuña-Villaorduña (4377628), Moises Palaci (3156573), Kevin P. Fennelly (798455), Mary Gaeddert (591524), Reynaldo Dietze (562728), Edward C. Jones-López (227412), Luiz Guilherme Schmidt-Castellani (5904941), Jerrold J. Ellner (227472), David Jamil Hadad (591521)   +10 more
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

A multivariable algorithm to predict risk of active tuberculosis in people with HIV infection using a composite risk factor of HIV viral load, CD4 cell count and interferon-gamma release assay (IGRA) result.

, 2015
A multivariable algorithm to predict risk of active tuberculosis in people with HIV infection using a composite risk factor of HIV viral load, CD4 cell count and interferon-gamma release assay (IGRA) result.
Hsi-Hsun Lin (473561), Kuan-Sheng Wu (784205), Hsin-Yun Sun (61134), Jui-Kuang Chen (784206), Susan Shin-Jung Lee (784202), Chien-Chin Hung (784203), Ih-Jen Su (87501), Chi-Tai Fang (125570), Chin-Hui Yang (450823), Hung-Chin Tsai (673178), Yao-Shen Chen (139714), Cheng-Len Sy (784204)   +11 more
core   +1 more source

Latent tuberculosis infection among medical students in Malaysia

Asian Pacific Journal of Tropical Medicine, 2019
Objective: This study aimed to determine prevalence of latent tuberculosis infection among medical students and tuberculosis exposure at the health facilities.
Maha Abdullah, Ummi Nadira Daut, Siti Aishah Daud, Nor Afifi Mohd Romli, Marsitah Abdul Jalil, Noorelina Muhammad, Safarina Mohammad Ismuddin, Masriana Hassan   +7 more
doaj   +1 more source