Results 181 to 190 of about 118,295 (302)

Antitubercular therapy for uveitis of undetermined cause with positive interferon-gamma release assay: a single-blind, single-centre, phase 2 randomised controlled trial. [PDF]

EClinicalMedicine
La Distia Nora R, Putera I, Riasanti M, Sitompul R, Edwar L, Susiyanti M, Aziza Y, Waliyuddin MZ, Widodo E, Sifyana UA, Jessica P, Ethelind R, Singh G, Dik WA, Rombach SM, van Hagen PM.   +15 more
europepmc   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Interferon-gamma release assay has poor diagnostic accuracy in differentiating intestinal tuberculosis from Crohn's disease in tuberculosis endemic areas. [PDF]

Intest Res, 2023
Sachdeva K, Kumar P, Kante B, Vuyyuru SK, Mohta S, Ranjan MK, Singh MK, Verma M, Makharia G, Kedia S, Ahuja V.   +10 more
europepmc   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Evaluation of an interferon-gamma release assay for early detection of lumpy skin disease virus infection and vaccination in cattle. [PDF]

Microbiol Spectr
Kresic N, Philips W, Haegeman A, de Regge N.   +3 more
europepmc   +1 more source

Interferon Gamma Release Assay and Tuberculin Skin Test Performance in Pregnant Women Living With and Without HIV. [PDF]

J Acquir Immune Defic Syndr, 2022
Kaplan SR, Escudero JN, Mecha J, Richardson BA, Maleche-Obimbo E, Matemo D, Kinuthia J, John-Stewart GC, LaCourse SM.   +8 more
europepmc   +1 more source

Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy

Advanced Science, EarlyView.
A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao, Shan Qiao, Jie Bai, Jingjing Zhang, Zhiqin Xi, Zhenzhen Li, Xuelin Zhan, Ying Zhang, Xiaotong Yu, Yao Chen, Yijin Liu   +10 more
wiley   +1 more source

Screening for Latent Tuberculosis Across Chronic Kidney Disease Stages Using Interferon-Gamma Release Assay: Findings from a National Infectious Disease Institute in Thailand. [PDF]

Trop Med Infect Dis
Pongpirul W, Pongpirul K, Tiabrat V, Muennoo K, Prasithsirikul W.   +4 more
europepmc   +1 more source

Comparison of interferon gamma release assay and CXCL9 gene expression assay for the detection of Mycobacterium bovis infection in African lions (Panthera leo). [PDF]

Front Cell Infect Microbiol, 2022
Gumbo R, Sylvester TT, Parsons SDC, Buss PE, Warren RM, van Helden PD, Miller MA, Kerr TJ.   +7 more
europepmc   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source