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Interferon-gamma release assays and TB diagnosis
Drug and Therapeutics Bulletin, 2009Worldwide in 2007, there were an estimated 9.27 million new cases of active tuberculosis (TB) and 1.8 million deaths related to the disease. However, in most people with TB, the infection is 'latent'; the underlying cause, Mycobacterium tuberculosis, remains alive but patients are asymptomatic and non-infectious.
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Interferon-gamma release assays for tuberculosis: current and future applications
Expert Review of Respiratory Medicine, 2013Interferon-gamma release assays (IGRAs) represent the first new tool to diagnose latent tuberculosis infection for more than 100 years. They have advantages over the traditional tuberculin skin test which has a poor specificity due to false-positive responses in people who are BCG vaccinated as there is a cross-reactivity of proteins present in both ...
Muhunthan, Thillai +3 more
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Interferon gamma release assays for diagnosing active and latent tuberculosis
Expert Opinion on Medical Diagnostics, 2009In view of the continuing global epidemic of tuberculosis (TB), adequate diagnosis is crucial for controlling this disease. Two commercial interferon gamma release assays (IGRA) have become available: the QuantiFERON-TB (QFT) and the T-SPOT.TB (TSPOT). They offer an important new tool for detecting both latent and active TB.
Steven Ft, Thijsen, Ailko Wj, Bossink
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Screening for Mycobacterium tuberculosis Using an Interferon-Gamma Release Assay
Journal of Public Health Management and Practice, 2012The Centers for Disease Control and Prevention recommend analyzing characteristics of populations screened for Mycobacterium tuberculosis infection using interferon-gamma release assays (IGRAs).We characterized requests for IGRA analyses submitted to the first laboratory in Washington State that began to offer IGRAs as a tuberculosis screening test. In
Terri, Simpson +3 more
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[Research agenda of interferon-gamma release assays].
Kekkaku : [Tuberculosis], 2009Recently, new diagnostic tests for tuberculosis infection that are more specific than tuberculin skin tests have been developed and have become commercially available. These tests determine interferon-gamma production after stimulation with M. tuberculosis-specific antigens, ESAT-6 and CFP-10, and are named Interferon-Gamma Release Assays (IGRA ...
Kazue, Higuchi, Nobuyuki, Harada
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Interferon-gamma-release assay prevents unnecessary tuberculosis therapy.
The Israel Medical Association journal : IMAJ, 2015The mass influx of immigrants from tuberculosis-endemic countries into Israel was followed by a considerable increase in the incidence of tuberculosis (TB). All contacts of active TB patients are obliged to be screened by tuberculin skin tests (TST) and, if found positive, prophylactic treatment is considered.To assess the utility of interferon-gamma ...
Vered, Schichter-Konfino +8 more
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Interferon-gamma Release Assays
DMW - Deutsche Medizinische Wochenschrift, 2007A Schablon, A Niehaus
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Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection
Laboratory medicine, 2009The aim of this report is to present results of serial interferon-gamma (IFN-γ ) determination (QuantiFERON-TB Gold In-Tube assay) in a 57-year-old BCG-vaccinated female health care worker with a latent tuberculosis infection. Increased IFN-γ , IgA, and anti-thyroglobulin (anti-Tg) autoantibodies were recorded throughout a 13-month follow-up.
Zrinski Topić, Renata, Dodig, Slavica
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Comparison of Two Interferon-Gamma Release Assays for Pediatric Tuberculosis Infection
Journal of the Pediatric Infectious Diseases SocietyAbstract Introduction Identifying tuberculosis infection (TBI) using interferon-gamma release assays (IGRAs) is a primary component of clinical and public health efforts to prevent pediatric tuberculosis (TB). Pediatric data comparing the 2 IGRAs in the United States are very limited.
James T, Gaensbauer +4 more
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