Results 41 to 50 of about 40,011 (243)

Diagnostic Utility of Interferon-Gamma Release Assay in Tuberculous Lymphadenitis [PDF]

Chinese Medical Sciences Journal, 2019
Objective The aim of this study was to evaluate the diagnostic performance of T-SPOT.TB for tuberculous lymphadenitis. Methods Suspected tuberculous lymphadenitis patients between September 2010 and September 2018 who had both peripheral blood T-SPOT.TB test and lymph node biopsy were retrospectively enrolled in this study.
Xin-Chao, Liu, Su-Su, Ye, Wen-Ze, Wang, Yue-Qiu, Zhang, Li-Fan, Zhang, Xiao-Cheng, Pan, Zi-Yue, Zhou, Miao-Yan, Zhang, Jiang-Hao, Liu, Zhi-Yong, Liang, Xiao-Qing, Liu   +10 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays

BMC Infectious Diseases, 2011
Background There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-g Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).
Mwananyanda Lawrence, Kilembe William, Wendt Joyanna, Mutemba Charles, Gonzalez-Diaz Esteban, Talati Naasha J, Chomba Elwyn, Allen Susan, del Rio Carlos, Blumberg Henry M   +9 more
doaj   +1 more source

Potential Role for Mycobacterium tuberculosis Specific IL-2 and IFN-γ Responses in Discriminating between Latent Infection and Active Disease after Long-Term Stimulation. [PDF]

PLoS ONE, 2016
Interferon gamma release assays (IGRAs) could accurately diagnose Mycobacterium tuberculosis (M.tuberculosis) infection. However, these assays do not discriminate between latent tuberculosis infection (LTBI) and active tuberculosis disease (ATB). Here, a
Qin Sun, Wei Wei, Wei Sha
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

INF-gamma Release ELISpot Assay

Bio-Protocol, 2012
IFN-γ (Interferon-gamma) is produced mainly by activated T cells and NK cells. Production of IFN-γ (Interferon-gamma) by helper T cells as well as cytotoxic T cells is a hallmark of the TH1-type phenotype, thus, high-level production of IFN-γ (Interferon-
Huagang Zhang
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Application and Interpretation of an Interferon-Gamma Release Assay: Results of an Audit in a Canadian Centre

Canadian Journal of Infectious Diseases and Medical Microbiology, 2012
BACKGROUND: Interferon-gamma release assays (IGRAs) are newly approved for diagnosing latent tuberculosis infection (LTBI). An internal audit was conducted to review the use of a newly implemented IGRA at the Hôpital du Sacré-Coeur de Montréal (Montréal,
Sopharat Vat, Marc Ghannoum, Pierre Laflamme, Mario Dugas, Manon Labrecque, Valéry Lavergne   +5 more
doaj   +1 more source

Miliary Tuberculosis with Indeterminate Interferon Gamma Release Assay Results

Internal Medicine, 2013
Recently, interferon gamma release assays (IGRAs) have become an important clinical tool for detecting latent tuberculosis. However, IGRA results may impede making a diagnosis. We herein present an interesting case of miliary tuberculosis with a nonspecific IGRA reaction due to hemophagocytosis.
Takahito, Nei, Yousuke, Fujisawa, Yuuki, Izumi, Akito, Tetsuka, Yosie, Arita, Hiroshige, Murata, Keisuke, Sawai, Mitsunobu, Kitamura, Hideki, Miyachi, Yusuke, Hosokawa, Koichi, Akutsu, Takeshi, Yamamoto, Keiji, Tanaka, Akihiro, Shinoyama   +13 more
openaire   +3 more sources

Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay [PDF]

Clinical and Vaccine Immunology, 2009
ABSTRACT Interferon gamma release assays (IGRAs) have been shown to be sensitive and highly specific for the detection of immune memory against Mycobacterium tuberculosis . Little is known about the reproducibility and within-person variability of these assays. Various aspects of short-term reproducibility
A K, Detjen, L, Loebenberg, H M S, Grewal, K, Stanley, A, Gutschmidt, C, Kruger, N, Du Plessis, M, Kidd, N, Beyers, G, Walzl, A C, Hesseling   +10 more
openaire   +2 more sources