Results 51 to 60 of about 41,796 (143)

Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2019
The tuberculin skin test and interferon-gamma release assays have limitations in diagnosing tuberculosis (TB), particularly in children. This study investigated the performance of candidate M.
Eva L. Sudbury, Larissa Otero, Marc Tebruegge, Nicole L. Messina, Carlos Seas, Martin Montes, Julia Rìos, Susie Germano, Kaya Gardiner, Vanessa Clifford, Eduardo Gotuzzo, Nigel Curtis   +11 more
doaj   +1 more source

Principles and clinical applications of interferon-gamma release assays in latent tuberculosis diagnosis

Annals of Clinical Microbiology
Latent tuberculosis (TB) refers to a state in which an individual is infected with Mycobacterium tuberculosis but shows no clinical symptoms. The World Health Organization estimates that 23% of the global population has latent TB, which poses a ...
Ha-eun Cho, Young Jin Kim
doaj   +1 more source

Use of Interferon-Gamma Release Assays in a Health Care Worker Screening Program: Experience from a Tertiary Care Centre in the United States

Canadian Respiratory Journal, 2012
BACKGROUND: Interferon-gamma release assays including the QuantiFERON-TB Gold In-Tube test (QFT-GIT [Cellestis Ltd, Australia]) may be used in place of the tuberculin skin test (TST) in surveillance programs for Mycobacterium tuberculosis infection ...
Manish Joshi, Thomas P Monson, Gail L Woods   +2 more
doaj   +1 more source

Diagnostic utility of interferon-gamma release assay in extrapulmonary tuberculosis

Diagnostic Microbiology and Infectious Disease, 2015
Early diagnosis of extrapulmonary tuberculosis (EP-TB) is essential. However, diagnosis of EP-TB is difficult. We evaluated the diagnostic utility of an interferon-gamma release assay (IGRA) in diagnosing active EP-TB among suspected patients in Korea.
Jung Ar, Shin, Yoon Soo, Chang, Hyung Jung, Kim, Chul Min, Ahn, Min Kwang, Byun   +4 more
openaire   +3 more sources

Miliary Tuberculosis with Indeterminate Interferon Gamma Release Assay Results

Internal Medicine, 2013
Recently, interferon gamma release assays (IGRAs) have become an important clinical tool for detecting latent tuberculosis. However, IGRA results may impede making a diagnosis. We herein present an interesting case of miliary tuberculosis with a nonspecific IGRA reaction due to hemophagocytosis.
Nei, Takahito, Fujisawa, Yousuke, Izumi, Yuuki, Tetsuka, Akito, Arita, Yosie, Murata, Hiroshige, Sawai, Keisuke, Kitamura, Mitsunobu, Miyachi, Hideki, Hosokawa, Yusuke, Akutsu, Koichi, Yamamoto, Takeshi, Tanaka, Keiji, Shinoyama, Akihiro   +13 more
openaire   +3 more sources

The evolution and role of interferon gamma release assays (IGRAs) in moderate and low income settings.

Sri Lankan Journal of Infectious Diseases, 2014
The interferon gamma release assays have been extensively evaluated in the diagnosis of latent tuberculosis infection as well as in diagnosis of active pulmonary and extra-pulmonary tuberculosis since their introduction just over a decade ago.
C N Ratnatunga
doaj   +1 more source

Comparing interferon-gamma release assays to tuberculin skin test in Thai children with tuberculosis exposure.

PLoS ONE, 2014
BackgroundData on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia.
Hong-Van Tieu, Piyarat Suntarattiwong, Thanyawee Puthanakit, Tawee Chotpitayasunondh, Kulkanya Chokephaibulkit, Sunee Sirivichayakul, Supranee Buranapraditkun, Patcharawee Rungrojrat, Nitiya Chomchey, Simon Tsiouris, Scott Hammer, Vijay Nandi, Jintanat Ananworanich, Thai TB Px Study Group   +13 more
doaj   +1 more source

Interferon-Gamma Release Assay Performance in Pulmonary and Extrapulmonary Tuberculosis

PLoS ONE, 2012
The diagnosis of tuberculosis remains difficult. This study aimed to assess performance of interferon-gamma release assay (IGRA) in diagnosis of active tuberculosis (ATB) with pulmonary and extrapulmonary involvements, and to determine the diagnostic role of IGRA (T-SPOT.TB) and tuberculin skin test (TST) in BCG-vaccinated population.Two hundred twenty-
Yun Feng, Ni Diao, Lingyun Shao, Jing Wu, Shu Zhang, Jialin Jin, Feifei Wang, Xinhua Weng, Ying Zhang, Wenhong Zhang   +9 more
openaire   +4 more sources

Interferon-gamma release assays for the tuberculosis serial testing of health care workers: a systematic review

Journal of Occupational Medicine and Toxicology, 2012
Background Interferon-gamma release assays (IGRAs) are increasingly used in the tuberculosis (TB) screening of health care workers (HCWs). However, comparatively high rates of conversions and reversion as well as growing evidence of substantial within ...
Ringshausen Felix C, Schablon Anja, Nienhaus Albert   +2 more
doaj   +1 more source

A novel non-invasive diagnostic approach based on urine and blood: a cross-sectional study combining lipoarabinomannan antigen and interferon-gamma release assay for active tuberculosis

Frontiers in Immunology
PurposeTo evaluate the diagnostic value of a combined strategy using the urine lipoarabinomannan (LAM) antigen assay and interferon-gamma release assay (IGRA) for active tuberculosis (TB), and to explore its potential as a non-invasive, sputum ...
Long Cai, Mingzhi Zhu, Tingting Fang, Qianqian Peng, Lingshan Dai, YanQin Shao, Libin Liu   +6 more
doaj   +1 more source