Cell Reports Medicine, 2020 Summary: Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment and prevention. Previously, we found that topical rectal tenofovir gel caused immunological changes in the mucosa.
Sean M. Hughes +29 more
doaj +1 more source
One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)
Frontiers in Microbiology, 2020 The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection.
A. Cristina Gonzalez-Perez +5 more
doaj +1 more source
DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling
Frontiers in Cell and Developmental Biology, 2022 DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses.
Rong Shen +6 more
doaj +1 more source
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. [PDF]
, 2012 We describe the course and likely pathophysiology of impending anterior ischemic optic neuropathy (AION) and retinal vein occlusion in a 56-year-old man with polycythemia vera managed with interferon alpha for 2 years.
Hirsch, Louis K +2 more
core +1 more source
Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy. [PDF]
, 2010 A large body of evidence suggests that, besides their cholesterol-lowering effect, statins exert anti-inflammatory action. Consequently, statins may have therapeutic potential in immune-mediated disorders such as multiple sclerosis.
BRESCIA MORRA, VINCENZO +13 more
core +1 more source
Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection
Frontiers in Immunology, 2016 The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using
Takahisa Kouwaki +11 more
doaj +1 more source
Frontiers in Microbiology, 2021 The non-structural protein 1 (NS1) of influenza A viruses plays important roles in viral fitness and in the process of interspecies adaptation.
Danyel Evseev, Katharine E. Magor
doaj +1 more source
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]
, 1992 Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Jonjic, Stipan +4 more
core +2 more sources
The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response
Frontiers in Cell and Developmental Biology, 2020 It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response.
Mariska van Huizen, Marjolein Kikkert
doaj +1 more source
Frontiers in Virology, 2021 Zika virus (ZIKV) is an arthropod-borne Flavivirus that can also be transmitted vertically from infected mother to fetus. Infection of the fetus during pregnancy can lead to congenital malformations and severely impact fetal brain development causing a ...
Nicole N. Haese +18 more
doaj +1 more source