Results 11 to 20 of about 1,165,655 (405)

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, Nikaïa Smith, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, Nicolas Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Nature Communications, 2020
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012.
T. Sheahan, A. Sims, S. Leist, A. Schäfer, John J. Won, Ariane J. Brown, S. Montgomery, A. Hogg, D. Babusis, M. Clarke, Jamie E. Spahn, L. Bauer, S. Sellers, D. Porter, Joy Y. Feng, T. Cihlář, R. Jordan, M. Denison, R. Baric   +18 more
semanticscholar   +1 more source

Double-edged effects of interferons on the regulation of cancer-immunity cycle

OncoImmunology, 2021
Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types.
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Xiaobo Li   +7 more
doaj   +1 more source

High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry

Frontiers in Immunology, 2022
The establishment of an “interferon (IFN) signature” to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate IFN signaling in SLE using multiplexed protein arrays and single cell cytometry by time of flight
Gloria Yiu, Gloria Yiu, Tue Kruse Rasmussen, Tue Kruse Rasmussen, Tue Kruse Rasmussen, Brandon L. Tsai, Vivian K. Diep, David J. Haddon, Jennifer Tsoi, Gopika D. Miller, Begoña Comin-Anduix, Begoña Comin-Anduix, Begoña Comin-Anduix, Bent Deleuran, Bent Deleuran, Gay M. Crooks, Gay M. Crooks, Gay M. Crooks, Gay M. Crooks, Paul J. Utz, Paul J. Utz   +20 more
doaj   +1 more source

Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial

Cancer Medicine, 2021
Preclinical observations that killing of chronic lymphocytic leukemia (CLL) cells was dexamethasone (DEX) were enhanced by concomitant inhibition of Bruton’s tyrosine kinase and janus kinases (JAKs) motivated a phase II trial to determine if clinical ...
David E. Spaner, Yuxuan Luo, Guizhei Wang, Jennifer Gallagher, Hubert Tsui, Yonghong Shi   +5 more
doaj   +1 more source

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Frontiers in Immunology, 2022
Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem, Mustafa H. Ghanem, Andrew J. Shih, Houman Khalili, Emily G. Werth, Jayanta K. Chakrabarty, Lewis M. Brown, Kim R. Simpfendorfer, Kim R. Simpfendorfer, Peter K. Gregersen, Peter K. Gregersen   +10 more
doaj   +1 more source

Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. [PDF]

, 2012
We describe the course and likely pathophysiology of impending anterior ischemic optic neuropathy (AION) and retinal vein occlusion in a 56-year-old man with polycythemia vera managed with interferon alpha for 2 years.
Hirsch, Louis K, Rue, Kelly S, Sadun, Alfredo A   +2 more
core   +1 more source

Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy. [PDF]

, 2010
A large body of evidence suggests that, besides their cholesterol-lowering effect, statins exert anti-inflammatory action. Consequently, statins may have therapeutic potential in immune-mediated disorders such as multiple sclerosis.
BRESCIA MORRA, VINCENZO, BRUNETTI, ARTURO, CAROTENUTO, BARBARA, LANZILLO, ROBERTA, Lus G, OREFICE, GIUSEPPE, Prinster A, Quarantelli M, RINALDI, CARLO, SALVATORE, ELENA, Spitaleri D, Tedeschi G, Vacca G, Ventrella G   +13 more
core   +1 more source

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted.
R. Motzer, Thomas E. Hutson, P. Tomczak, M. Michaelson, R. Bukowski, O. Rixe, S. Oudard, S. Négrier, C. Szczylik, Sindy T. Kim, I. Chen, P. Bycott, C. Baum, R. Figlin   +13 more
semanticscholar   +1 more source

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ, Bengoechea, JA, Fernández, Y, Killip, MJ, Oliveros, JC, Ortín, J, Pérez-Cidoncha, M, Randall, RE   +7 more
core   +2 more sources