Results 11 to 20 of about 779,562 (365)

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, Nikaïa Smith, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, N. Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Nature Communications, 2020
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012.
T. Sheahan, A. Sims, S. Leist, A. Schäfer, John J. Won, Ariane J. Brown, S. Montgomery, A. Hogg, D. Babusis, M. Clarke, Jamie E. Spahn, L. Bauer, S. Sellers, D. Porter, Joy Y. Feng, T. Cihlář, R. Jordan, M. Denison, R. Baric   +18 more
semanticscholar   +1 more source

Double-edged effects of interferons on the regulation of cancer-immunity cycle

OncoImmunology, 2021
Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types.
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Xiaobo Li   +7 more
doaj   +1 more source

High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry

Frontiers in Immunology, 2022
The establishment of an “interferon (IFN) signature” to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate IFN signaling in SLE using multiplexed protein arrays and single cell cytometry by time of flight
Gloria Yiu, Gloria Yiu, Tue Kruse Rasmussen, Tue Kruse Rasmussen, Tue Kruse Rasmussen, Brandon L. Tsai, Vivian K. Diep, David J. Haddon, Jennifer Tsoi, Gopika D. Miller, Begoña Comin-Anduix, Begoña Comin-Anduix, Begoña Comin-Anduix, Bent Deleuran, Bent Deleuran, Gay M. Crooks, Gay M. Crooks, Gay M. Crooks, Gay M. Crooks, Paul J. Utz, Paul J. Utz   +20 more
doaj   +1 more source

Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial

Cancer Medicine, 2021
Preclinical observations that killing of chronic lymphocytic leukemia (CLL) cells was dexamethasone (DEX) were enhanced by concomitant inhibition of Bruton’s tyrosine kinase and janus kinases (JAKs) motivated a phase II trial to determine if clinical ...
David E. Spaner, Yuxuan Luo, Guizhei Wang, Jennifer Gallagher, Hubert Tsui, Yonghong Shi   +5 more
doaj   +1 more source

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Frontiers in Immunology, 2022
Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem, Mustafa H. Ghanem, Andrew J. Shih, Houman Khalili, Emily G. Werth, Jayanta K. Chakrabarty, Lewis M. Brown, Kim R. Simpfendorfer, Kim R. Simpfendorfer, Peter K. Gregersen, Peter K. Gregersen   +10 more
doaj   +1 more source

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted.
R. Motzer, Thomas E. Hutson, P. Tomczak, M. Michaelson, R. Bukowski, O. Rixe, S. Oudard, S. Négrier, C. Szczylik, Sindy T. Kim, I. Chen, P. Bycott, C. Baum, R. Figlin   +13 more
semanticscholar   +1 more source

Anemia de Doença Crônica [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2002
Anemia de Doença Crônica (ADC) é usualmente definida como a anemia que ocorre em distúrbios infecciosos crônicos, inflamatórios ou doenças neoplásicas, e é uma das síndromes clínicas mais comuns na prática clínica.
Rodolfo D. Cançado, Carlos S. Chiattone
doaj   +1 more source

The Role of Type I IFNs in Influenza: Antiviral Superheroes or Immunopathogenic Villains?

Journal of Innate Immunity, 2020
The important role of interferons (IFNs) in antiviral innate immune defense is well established. Although recombinant IFN-α was approved for cancer and chronic viral infection treatment by regulatory agencies in many countries starting in 1986, no IFNs ...
Wenxin Wu, Jordan P. Metcalf
doaj   +1 more source

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Science, 2013
DNA Sensing Is a (c)GAS DNA is normally localized to the nucleus, and so its cytoplasmic localization sends off alarm bells to the immune system because it indicates that a virus may have entered.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J. Chen   +4 more
semanticscholar   +1 more source