Results 11 to 20 of about 132,342 (218)

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

Frontiers in Cell and Developmental Biology, 2022
DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses.
Rong Shen, Disheng Liu, Xiaoning Wang, Zhao Guo, Haonan Sun, Yanfeng Song, Degui Wang   +6 more
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Molecular Evolution of the Influenza A Virus Non-structural Protein 1 in Interspecies Transmission and Adaptation

Frontiers in Microbiology, 2021
The non-structural protein 1 (NS1) of influenza A viruses plays important roles in viral fitness and in the process of interspecies adaptation.
Danyel Evseev, Katharine E. Magor
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The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response

Frontiers in Cell and Developmental Biology, 2020
It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response.
Mariska van Huizen, Marjolein Kikkert
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Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy

Frontiers in Virology, 2021
Zika virus (ZIKV) is an arthropod-borne Flavivirus that can also be transmitted vertically from infected mother to fetus. Infection of the fetus during pregnancy can lead to congenital malformations and severely impact fetal brain development causing a ...
Nicole N. Haese, Hannah Smith, Kosiso Onwuzu, Craig N. Kreklywich, Jessica L. Smith, Michael Denton, Nicholas Kreklywich, Aaron D. Streblow, Antonio E. Frias, Antonio E. Frias, Terry K. Morgan, Terry K. Morgan, Alec J. Hirsch, Alec J. Hirsch, Benjamin N. Bimber, Benjamin N. Bimber, Victoria H. J. Roberts, Daniel N. Streblow, Daniel N. Streblow   +18 more
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Inhibition of PI3Kδ Differentially Regulates Poly I:C– and Human Metapneumovirus–Induced PD–L1 and PD–L2 Expression in Human Bronchial Epithelial Cells

Frontiers in Immunology, 2021
Bronchial epithelial cells are front sentinels eliciting innate and adaptive immunity to respiratory viral pathogens. Recognition of viral double-stranded RNA induces antiviral interferon (IFN) responses in bronchial epithelial cells.
Tomohiro Ogawa, Keiko Kan-o, Keiko Kan-o, Ayaka Shiota, Akitaka Fujita, Yumiko Ishii, Satoru Fukuyama, Koichiro Matsumoto   +7 more
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Comparison of Pegylated Interferon Alfa Therapy in Combination with Tenofovir Alafenamide Fumarate or Tenofovir Disoproxil Fumarate for Treatment of Chronic Hepatitis B Patients

Infection and Drug Resistance, 2023
Jingjing He, Yifei Guo, Yao Zhang, Jiajia Han, Jingwen Chen, Yidi Jia, Zhenxuan Ma, Jingwen Wu, Shenyan Zhang, Fahong Li, Richeng Mao, Jiming Zhang Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ...
He J, Guo Y, Zhang Y, Han J, Chen J, Jia Y, Ma Z, Wu J, Zhang S, Li F, Mao R, Zhang J   +11 more
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Treatment options in non-muscle-invasive bladder cancer after BCG failure

Indian Journal of Urology, 2015
Bladder cancer is the ninth-most prevalent cancer worldwide. Most patients with urothelial cell carcinoma of the bladder present with non-muscle-invasive disease and are treated with bacillus Calmette-Guérin (BCG) intravesical therapy.
Nathan A Brooks, Michael A O'Donnell
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Transcriptome Analysis of Lungs in a Mouse Model of Severe COVID-19

Frontiers in Virology, 2022
Severe manifestations of coronavirus disease 2019 (COVID-19) are mostly restricted to distinct groups of people who have preexisting morbidities. Most COVID-19 animal models develop a mild pathology that resolves within a relatively short period of time,
Inbar Cohen-Gihon, Ofir Israeli, Avital Tidhar, Anita Sapoznikov, Yentl Evgy, Dana Stein, Moshe Aftalion, David Gur, Irit Orr, Anat Zvi, Tamar Sabo, Chanoch Kronman, Reut Falach   +12 more
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Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis

Frontiers in Immunology, 2019
Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the host innate immune response in pathogenesis ...
Catherine F. Hatton, Christopher J. A. Duncan, Christopher J. A. Duncan   +2 more
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Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells

Journal of Immunotoxicology, 2019
Endosulfan is a DDT-era organochlorine pesticide. Due to past and current environmental contamination, investigation of endosulfan exposure is of current importance. Acute high dose exposure precipitates neural/endocrine system damage, but the effects on
Martha Cecilia Téllez-Bañuelos, Salvador González-Ochoa, Pablo Cesar Ortiz-Lazareno, Vida Celeste Rosas-Gonzalez, Jaime Gómez-Villela, Jesse Haramati   +5 more
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