Results 11 to 20 of about 582,181 (313)
Melanoma Management, 2018 Aim: We assessed the role of adjuvant interferon on relapse-free survival (RFS), distant metastasis-free survival (DMFS) and overall survival (OS) in node-positive melanoma patients. Methods: We retrospectively reviewed 385 node-positive patients without
Daniel E Oliver +11 more
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Hepatic Oncology, 2018 Aim: Recent studies raise concerns for higher incidence of hepatocellular carcinoma (HCC) after direct-acting antiviral therapy for hepatitis C virus (HCV).
Gabriela Kuftinec +6 more
doaj +1 more source
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy
Frontiers in Oncology, 2021 Cancers, including lymphomas, develop in complex tissue environments where malignant cells actively promote the creation of a pro-tumoral niche that suppresses effective anti-tumor effector T cell responses.
Benedetta Apollonio +3 more
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Frontiers in Immunology, 2022 Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem +10 more
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Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis
Türk Oftalmoloji Dergisi, 2016 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 ...
Haluk Esgin
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Successful treatment of hairy cell leukaemia with pegylated interferon-alpha-2A
Pathology and Oncology ResearchIntroductionHairy cell leukemia (HCL) is an indolent B-cell lymphoproliferative disease. Interferon-alpha (IFN-alpha) was the first successfully used drug in HCL; its favourable effect has been known since the early 1980s.
Kata Ferenczi +6 more
doaj +1 more source
Frontiers in MedicineBackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood.
Anikó E. Malik +12 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection
Frontiers in Immunology, 2016 The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using
Takahisa Kouwaki +11 more
doaj +1 more source