Results 21 to 30 of about 779,562 (365)

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease.
G. Hudes, M. Carducci, P. Tomczak, J. Dutcher, R. Figlin, A. Kapoor, E. Starosławska, J. Sosman, D. McDermott, I. Bodrogi, Z. Kovačević, V. Lesovoy, I. Schmidt-Wolf, O. Barbarash, E. Gokmen, T. O'Toole, S. Lustgarten, L. Moore, R. Motzer   +18 more
semanticscholar   +1 more source

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

Emerging Microbes and Infections, 2020
The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infections worldwide (
Chun-Kit Yuen, J. Lam, Wan-Man Wong, L. Mak, Xiaohui Wang, Hin Chu, Jian-Piao Cai, D. Jin, K. To, J. Chan, K. Yuen, K. Kok   +11 more
semanticscholar   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud   +13 more
wiley   +1 more source

The ability inhibition Gumboro disease virus in 3-week-old chickens of chicken Interferon Alpha

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2020
Virus-infectious diseases are permanent threats and cause serious lost for chicken industry of our country. Recombinant chicken interferon alpha (rChIFN-α) were expressed successfully on yeast pichia pastorisand was functional ...
Nguyễn Thị Thanh Giang, Hồ Quảng Đồ, Nguyễn Đăng Quân   +2 more
doaj   +1 more source

The human antigen R as an actionable super-hub within the network of cancer cell persistency and plasticity [PDF]

Translational Oncology, Volume 35, 2023, 101722, ISSN 1936-5233, 2022
In this perspective article, a clinically inspired phenotype-driven experimental approach is put forward to address the challenge of the adaptive response of solid cancers to small-molecule targeted therapies. A list of conditions is derived, including an experimental quantitative assessment of cell plasticity and an information theory-based detection ...
arxiv   +1 more source

Dysregulation of type I interferon responses in COVID-19

Nature reviews. Immunology, 2020
Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted.
D. Acharya, Guanqun Liu, Michaela U. Gack   +2 more
semanticscholar   +1 more source

Interferon therapy of acute respiratory viral infections in children

Zdorovʹe Rebenka, 2017
The purpose of our study was to evaluate the efficacy and tolerability of nasal spray Laferobionum® (100,000 IU/ml) in children with acute respiratory viral infections. Materials and methods. The study included 84 children aged 12 to 18 years. Children
A.E. Abaturov, E.A. Agafonova
doaj   +1 more source

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.

New England Journal of Medicine, 2003
BACKGROUND Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic-phase chronic myeloid leukemia (CML) who have had no response to interferon alfa.
S. O’Brien, F. Guilhot, R. Larson, I. Gathmann, M. Baccarani, F. Cervantes, J. Cornelissen, T. Fischer, A. Hochhaus, T. Hughes, K. Lechner, J. L. Nielsen, P. Rousselot, J. Reiffers, G. Saglio, J. Shepherd, B. Simonsson, A. Gratwohl, J. Goldman, H. Kantarjian, K. Taylor, G. Verhoef, A. Bolton, R. Capdeville, B. Druker   +24 more
semanticscholar   +1 more source

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group.

New England Journal of Medicine, 1998
BACKGROUND Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy. We compared the efficacy and safety of recombinant interferon alfa-2b alone with those of a combination of interferon alfa-2b
J. Mchutchison, S. Gordon, E. Schiff, M. Shiffman, William M. Lee, V. Rustgi, Z. Goodman, M. Ling, S. Cort, J. Albrecht   +9 more
semanticscholar   +1 more source

Interferon-stimulated genes: a complex web of host defenses.

Annual Review of Immunology, 2014
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens.
W. Schneider, Meike Chevillotte, C. Rice
semanticscholar   +1 more source