Results 21 to 30 of about 1,165,655 (405)

Anemia de Doença Crônica [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2002
Anemia de Doença Crônica (ADC) é usualmente definida como a anemia que ocorre em distúrbios infecciosos crônicos, inflamatórios ou doenças neoplásicas, e é uma das síndromes clínicas mais comuns na prática clínica.
Rodolfo D. Cançado, Carlos S. Chiattone
doaj   +1 more source

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]

, 2017
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J., Cumberworth, Stephanie, Donald, Claire L., Kohl, Alain   +3 more
core   +1 more source

The Role of Type I IFNs in Influenza: Antiviral Superheroes or Immunopathogenic Villains?

Journal of Innate Immunity, 2020
The important role of interferons (IFNs) in antiviral innate immune defense is well established. Although recombinant IFN-α was approved for cancer and chronic viral infection treatment by regulatory agencies in many countries starting in 1986, no IFNs ...
Wenxin Wu, Jordan P. Metcalf
doaj   +1 more source

Raised serum transaminases during treatment with pegylated interferon for chronic hepatiti C [PDF]

, 2016
Introduction : Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin. Methods : 219 patients with chronic hepatitis C, genotypes 2 and 3, were treated
Datta, S., Mandalou, P., Mills, P.R., Spence, E.   +3 more
core   +1 more source

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease.
G. Hudes, M. Carducci, P. Tomczak, J. Dutcher, R. Figlin, A. Kapoor, E. Starosławska, J. Sosman, D. McDermott, I. Bodrogi, Z. Kovačević, V. Lesovoy, I. Schmidt-Wolf, O. Barbarash, E. Gokmen, T. O'Toole, S. Lustgarten, L. Moore, R. Motzer   +18 more
semanticscholar   +1 more source

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

Emerging Microbes and Infections, 2020
The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infections worldwide (
Chun-Kit Yuen, J. Lam, Wan-Man Wong, L. Mak, Xiaohui Wang, Hin Chu, Jian-Piao Cai, D. Jin, K. To, J. Chan, K. Yuen, K. Kok   +11 more
semanticscholar   +1 more source

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]

, 1992
Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Jonjic, Stipan, Koszinowski, Ulrich H., Lucin, Pero, Pavic, Ivica, Polic, Bojan   +4 more
core   +2 more sources

The human antigen R as an actionable super-hub within the network of cancer cell persistency and plasticity [PDF]

Translational Oncology, Volume 35, 2023, 101722, ISSN 1936-5233, 2022
In this perspective article, a clinically inspired phenotype-driven experimental approach is put forward to address the challenge of the adaptive response of solid cancers to small-molecule targeted therapies. A list of conditions is derived, including an experimental quantitative assessment of cell plasticity and an information theory-based detection ...
arxiv   +1 more source

Regulation of Murine Class I Genes by Interferons is Controlled by Regions Located Both 5' and 3' to the Transcription Initiation Site [PDF]

, 1987
Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2Ld and H-2Dd DNA ...
Hood, Leroy, Korber, Bette, Stroynowski, Iwona   +2 more
core   +1 more source

The ability inhibition Gumboro disease virus in 3-week-old chickens of chicken Interferon Alpha

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2020
Virus-infectious diseases are permanent threats and cause serious lost for chicken industry of our country. Recombinant chicken interferon alpha (rChIFN-α) were expressed successfully on yeast pichia pastorisand was functional ...
Nguyễn Thị Thanh Giang, Hồ Quảng Đồ, Nguyễn Đăng Quân   +2 more
doaj   +1 more source