Results 21 to 30 of about 132,342 (218)
mBio, 2021 Outbreaks of emerging viral pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a major medical challenge. There is a pressing need for antivirals that can be rapidly deployed to curb infection and dissemination. We determined
Sook-Young Sohn +10 more
doaj +1 more source
Regulation of hematopoietic stem cell activity by inflammation
Frontiers in Immunology, 2013 Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term ...
Laura eSchuettpelz, Daniel eLink
doaj +1 more source
Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells
Frontiers in Immunology, 2020 Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations.
Michael Sörensen +15 more
doaj +1 more source
The Interplay between the Host Microbiome and Pathogenic Viral Infections
mBio, 2021 The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by ...
Rubén González, Santiago F. Elena
doaj +1 more source
Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients
Frontiers in Immunology, 2017 Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by chronic brain inflammation. Leukocyte infiltration of brain tissue causes inflammation, demyelination, and the subsequent formation of sclerotic plaques, which are a ...
Timur Khaibullin +8 more
doaj +1 more source
Frontiers in Microbiology, 2018 H9N2 influenza A viruses (IAV) are considered low pathogenic avian influenza viruses (LPAIV). These viruses are endemic in poultry in many countries in Asia, the Middle East and parts of Africa.
Laura Rodriguez +5 more
doaj +1 more source
Russian Open Medical Journal, 2020 Background ― A number of studies confirmed a crucial role of type 1 interferon in pathophysiology of connective tissue diseases. Interferon regulatory factors (IRF) coordinate an expression of type 1 interferon, while interferon regulatory factor 5 (IRF5)
Mikhail Yu. Krylov +2 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundAltered innate defense mechanisms, including an imbalance between oxidants and antioxidants release, have been implicated in the pathogenesis of chronic rhinosinusitis (CRS).
Sang Hag Lee +6 more
doaj +1 more source
The IFITMs Inhibit Zika Virus Replication
Cell Reports, 2016 Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here,
George Savidis +6 more
doaj +1 more source
Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis
Frontiers in Immunology, 2023 Early detection of infection is a central and critical component of our innate immune system. Mammalian cells have developed specialized receptors that detect RNA with unusual structures or of foreign origin – a hallmark of many virus infections ...
Sarah Straub +3 more
doaj +1 more source