Results 31 to 40 of about 574,262 (313)

In turkeys, unlike chickens, the non-structural NS1 protein does not play a significant role in the replication and tissue tropism of the H7N1 avian influenza virus

Virulence
The economic losses caused by high pathogenicity (HP) avian influenza viruses (AIV) in the poultry industry worldwide are enormous. Although chickens and turkeys are closely related Galliformes, turkeys are thought to be a bridging host for the ...
Maryna Kuryshko, Maria Landmann, Christine Luttermann, Reiner Ulrich, Elsayed M. Abdelwhab   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Role of interferon regulatory factors in predicting the prognosis of Crimean-Congo hemorrhagic fever

Türk Biyokimya Dergisi
Crimean-Congo hemorrhagic fever (CCHF) is a severe viral illness with a high fatality rate. The interferon response plays a crucial role in the antiviral defense against the CCHF virus (CCHFV).
Öksüz Caner, Doğan Halef Okan, Zararsız Gökmen, Elaldı Nazif, Büyüktuna Seyit Ali   +4 more
doaj   +1 more source

Predictive value of hepatic, hematological, and immunological markers and their temporal dynamics in chronic hepatitis B functional cure

Microbiology Spectrum
Hepatitis B virus (HBV) infection remains a major global health burden. While interferon-alpha (IFNα) therapy demonstrates antiviral and immunomodulatory effects, reliable prognostic markers for sustained response are needed. Transaminases, hematological
Jianyong Zeng, Caixia Zheng, Yincheng Zheng, Xiulan Xue   +3 more
doaj   +1 more source

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

Frontiers in Microbiology, 2020
The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection.
A. Cristina Gonzalez-Perez, Markus Stempel, Markus Stempel, Baca Chan, Melanie M. Brinkmann, Melanie M. Brinkmann   +5 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison of Pegylated Interferon Alfa Therapy in Combination with Tenofovir Alafenamide Fumarate or Tenofovir Disoproxil Fumarate for Treatment of Chronic Hepatitis B Patients

Infection and Drug Resistance, 2023
Jingjing He, Yifei Guo, Yao Zhang, Jiajia Han, Jingwen Chen, Yidi Jia, Zhenxuan Ma, Jingwen Wu, Shenyan Zhang, Fahong Li, Richeng Mao, Jiming Zhang Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ...
He J, Guo Y, Zhang Y, Han J, Chen J, Jia Y, Ma Z, Wu J, Zhang S, Li F, Mao R, Zhang J   +11 more
doaj  

Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial [PDF]

, 2021
Ilad Alavi Darazam, Shervin Shokouhi, Mohamad Amin Pourhoseingholi, Seyed Sina Naghibi Irvani, Majid Mokhtari, Minoosh Shabani, Mahdi Amirdosara, Parham Torabinavid, Maryam Golmohammadi, SayedPayam Hashemi, Arsalan Azimi, Mohammad Hossein Jafarazadeh Maivan, Omidvar Rezaei, Alireza Zali, Mohammadreza Hajiesmaeili, Hadiseh Shabanpour Dehbsneh, Akram Hoseyni Kusha, Maryam Taleb Shoushtari, Negar Khalili, Azam Soleymaninia, Latif Gachkar, Ali Khoshkar   +21 more
openalex   +1 more source