Results 31 to 40 of about 779,562 (365)
Ocrelizumab versus Interferon Beta‐1a in Relapsing Multiple Sclerosis
New England Journal of Medicine, 2017 BACKGROUND B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized monoclonal antibody that selectively depletes CD20+ B cells. METHODS In two identical phase 3 trials, we randomly assigned 821 and 835 patients with relapsing
S. Hauser +20 more
semanticscholar +1 more source
Interferon-α2b Treatment for COVID-19
Frontiers in Immunology, 2020 The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. In
Qiong Zhou +9 more
semanticscholar +1 more source
Interferon‐γ: an overview of signals, mechanisms and functions
, 2004 Interferon‐γ (IFN‐γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN‐γ ligand, receptor, ignal transduction, and cellular effects
K. Schroder +3 more
semanticscholar +1 more source
The type I interferon response in COVID-19: implications for treatment
Nature reviews. Immunology, 2020 Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection.
Jeong Seok Lee, E. Shin
semanticscholar +1 more source
MDP Up-Regulates the Gene Expression of Type I Interferons in Human Aortic Endothelial Cells
Molecules, 2012 Muramyldipeptide (MDP), the minimum essential structure responsible for the immuno-adjuvant activity of peptidoglycan, is recognized by intracellular nuclear-binding oligomerization domain 2 (NOD2).
Xiumei Xie +8 more
doaj +1 more source
Time and length scales of autocrine signals in three dimensions [PDF]
Biophys J. 2007 Sep 15;93(6):1917-22, 2007 A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived.
arxiv +1 more source
Mathematical model of immune response to hepatitis B [PDF]
J. Theor. Biol. 447, 98-110 (2018), 2018 A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a ...
arxiv +1 more source
Interferon-Stimulated Genes: What Do They All Do?
Annual Review of Virology, 2019 In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs)
J. Schoggins
semanticscholar +1 more source
Viruses, 2015 Hepatitis C virus (HCV) infection is one of the leading causes of end-stage liver disease and the main indication for liver transplantation (LT) in most countries.
Bruno Roche +3 more
doaj +1 more source
Frontiers in Genetics, 2020 We describe a 2 year old boy with two previously undescribed frameshift mutations in the interferon (IFN)α/β receptor 2 (IFNAR2) gene presenting with hemophagocytic lymphohistiocytosis (HLH) following measles-mumps-rubella vaccination.
Chiara Passarelli +12 more
doaj +1 more source