Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host [PDF]
arXiv, 2017 How important is resource depletion (e.g. depletion of target cells) in controlling infection within a host? And how can we distinguish between resource depletion and other mechanisms that may contribute to decline of pathogen load or lead to pathogen clearance? In this paper we examine data from a previously published experiment.
arxiv
Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients
Frontiers in Immunology, 2017 Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by chronic brain inflammation. Leukocyte infiltration of brain tissue causes inflammation, demyelination, and the subsequent formation of sclerotic plaques, which are a ...
Timur Khaibullin +8 more
doaj +1 more source
Interferon Production by Inactivated Newcastle Disease Virus in Cell Cultures and in Mice [PDF]
, 1966 Julius S. Youngner +3 more
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Signal propagation in sensing and reciprocating cellular systems with spatial and structural heterogeneity [PDF]
arXiv, 2018 Sensing and reciprocating cellular systems (SARs) are important for the operation of many biological systems. Production in interferon (IFN) SARs is achieved through activation of the Jak-Stat pathway, and downstream upregulation of IFN regulatory factor (IRF)-3 and IFN transcription, but the role that high and low affinity IFNs play in this process ...
arxiv
Quantitative Aspects of Inhibition of Virus Replication by Interferon in Chick Embryo Cell Cultures [PDF]
, 1966 Jules V. Hallum, Julius S. Youngner
openalex +1 more source
REP: Predicting the Time-Course of Drug Sensitivity [PDF]
arXiv, 2019 The biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and difficult to discern. Time-course gene expression data is a rich source of information that can be used to unravel these complex processes, identify biomarkers of drug sensitivity and predict the response to a drug.
arxiv
An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia
Frontiers in Immunology, 2018 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia (CAP). Despite the low prevalence of CAP caused by methicillin-resistant Staphylococcus aureus (MRSA), CAP patients often receive empirical antibiotic therapy providing ...
Anja Strehlitz +4 more
doaj +1 more source
Co-Attentive Cross-Modal Deep Learning for Medical Evidence Synthesis and Decision Making [PDF]
arXiv, 2019 Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and epidemiological models.
arxiv
Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion
Viruses, 2019 Enteroviruses are a major source of human disease, particularly in neonates and young children where infections can range from acute, self-limited febrile illness to meningitis, endocarditis, hepatitis, and acute flaccid myelitis.
Alexandra I. Wells, Carolyn B. Coyne
doaj +1 more source
Induction of Ocular Resistance to Vaccinia Virus by Typhoid Vaccine: Role of Interferon [PDF]
, 1969 Jang O. Oh, Chieko Yoneda
openalex +1 more source