Results 21 to 30 of about 185,652 (250)

Correlation of Serum Interferon Gamma and Neopterin Concentrations in Africans with Various Diseases

Pteridines, 1989
Concentrations of interferon gamma in serum and of neopterin in serum and urine were determined in 55 Tanzanians attending a local hospital for various diseases or complaints. For comparison, serum concentrations of interferon gamma and of neopterin were
Reibnegger Gilbert, Fuchs Dietmar, Hausen Arno, Schmutzhard Erich, Werner Ernst R., Werner-Felmayer Gabriele, Dierich Manfred P., Wachter Helmut   +7 more
doaj   +1 more source

Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.

PLoS ONE, 2018
BackgroundWe previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic
Moises A Huaman, David Henson, Paola L Rondan, Eduardo Ticona, Gustavo Miranda, Richard J Kryscio, Raquel Mugruza, Ernesto Aranda, Cesar Ticona, Susan Abarca, Paula Heredia, Andres Aguirre, Timothy R Sterling, Beth A Garvy, Carl J Fichtenbaum   +14 more
doaj   +1 more source

Evaluation of Interferon-gamma Application for Recognition of Patients Afflicted by Non-healing Cutaneous Leishmaniasis [PDF]

Biological Journal of Microorganism, 2017
Introduction:Different studies undertaken in the animal modeling show that Interferon-gamma deficiency impairs healing process of Leishmania infection.
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Sayyed Hamid Zarkesh-Esfahani, Roya Taleban, Ali Asilian, Mohammad Ali Nilforoushzadeh, Fariba Jaffary, Marjan Mansourian, Fatemeh Sokhanvari, Nazli Ansari   +10 more
doaj  

The preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-γ (th1/th2 balance) in sensitized guinea pigs

Clinics, 2014
OBJECTIVE:The effects of natural adjuvants on lung inflammation and tracheal responsiveness were examined in sensitized guinea pigs.METHODS:The responses of guinea pig tracheal chains and the serum levels of interleukin-4 and interferon-gamma were ...
Mohammad Hossein Boskabady, Ali Neamati, Saleh Mohaghegh Hazrati, Mohammad Reza Khakzad, Shakeeb Hassan Moosavi, Zahra Gholamnezhad   +5 more
doaj   +1 more source

Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-γ, interleukin-4, tumor necrosis factor-α, or muramyl dipeptide

International Journal of Immunopathology and Pharmacology, 2017
Keratinocytes are routinely subjected to both internal and external stimulation. This study investigates the effects of interferon gamma, interleukin-4, tumor necrosis factor alpha, and the synthetic immunomodulator muramyl dipeptide on the human ...
Emale El Darzi, Samer Bazzi, Sarah Daoud, Karim S Echtay, Georges M Bahr   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Interferon gamma in cancer immunotherapy

Cancer Medicine, 2018
Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in ...
Ling Ni, Jian Lu
doaj   +1 more source

IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

Anais da Academia Brasileira de Ciências, 2023
Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined.
CAROLINA VÉLEZ, MARIÁNGELES CLAUZURE, DELIA WILLIAMSON, MIRTA A. KONCURAT, CLAUDIO BARBEITO   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source