Results 1 to 10 of about 128,935 (252)

Interferon gamma receptor: The beginning of the journey [PDF]

Frontiers in Immunology, 2013
Our view of endocytosis and membrane trafficking of transmembrane receptors has dramatically changed over the last 20 years. Several new endocytic routes have been discovered and mechanistically characterized in mammalian cells.
Christophe eLamaze, Cédric M. Blouin
doaj   +5 more sources

Disseminated mycobacterium avium complex spinal osteomyelitis in a patient with interferon gamma receptor deficiency: A case report [PDF]

Radiology Case Reports
Disseminated mycobacterium avium complex (MAC) infection is rare and is classically associated with immunodeficient states. Osteomyelitis is a rare manifestation of disseminated MAC infection. The overwhelming majority of MAC infections occur in patients
Sarah Jaggernauth, BS, Andrew Waack, BS, Alastair Hoyt, MD, Jason Schroeder, MD   +3 more
doaj   +4 more sources

The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections

International Journal of Mycobacteriology, 2021
Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) remain the leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its receptor (IFN-γR) play a key role in mediating immunity against Mtb and NTM.
Jalaledin Ghanavi, Poopak Farnia, Parissa Farnia, Ali Akbar Velayati   +3 more
doaj   +3 more sources

Systemic aspergillosis in a patient with interferon gamma receptor 1 deficiency; a case report [PDF]

BMC Pediatrics, 2023
Background Interferon-gamma receptor deficiency is a heterogeneous spectrum of disease which involves mutations in IFNGR1, IFNGR2 genes, and the downstream signaling proteins such as STAT1.
Hossein Esmaeilzadeh, Zahra Chavoshzadeh, Seyed Hesamedin Nabavizadeh, Soheila Alyasin, Ali Amanati, Aida Askarisarvestani   +5 more
doaj   +2 more sources

Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study [PDF]

The Turkish Journal of Gastroenterology, 2023
Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis.
Serdar Kaymaz, Murat Kavas, Aydın Demiray, Uğur Karasu, Veli Çobankara, Sibel Boğa   +5 more
doaj   +2 more sources

Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis. [PDF]

Pediatr Allergy Immunol, 2022
Background: Defects in IFN–gamma receptor (IFN-γR) signaling via STAT1 leads to susceptibility to infection by otherwise weak pathogenic mycobacteria, resulting in mendelian susceptibility to mycobacterial disease. We identified three patients presented with disseminated mycobacterial infections caused by M. avium, M. persicum or M.
Zhou Z, Hollink IHIM, Bouman A, Lourens MS, Brooimans RA, van Ham TJ, Fraaij PLA, van Rossum AMC, Zijtregtop EAM, Dik WA, Dalm VASH, van Hagen PM, Ijspeert H, Vermont CL.   +13 more
europepmc   +4 more sources

Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-γ R1) Defect: A Clinical Diagnostic and Treatment Challenge [PDF]

Case Reports in Infectious Diseases, 2022
Background. Mendelian susceptibility to mycobacterial diseases (MSMD) is an inborn error of immunity categorized as defects in intrinsic and innate immunity.
Netsanet Azene Gebeyehu, Solomie Jebessa Deribessa, Freeman Alexandra, Messay Tesfaye Demissie, W Mihretu Gebre, Aklilu Melaku Gebremariam, Dagmawit Mitiku Engliz, Tizita Yosef Kidane, Lidya Million Bekele, Abate Yeshidinber Weldetsadik   +9 more
doaj   +2 more sources

Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection [PDF]

Journal of Neuroinflammation
A craniotomy is a neurosurgical procedure performed to access the intracranial space. In 3–5% of cases, infections can develop, most caused by Staphylococcus aureus biofilm formation on the skull surface. Medical management of this infection is difficult,
Zachary Van Roy, Gunjan Kak, Rachel W. Fallet, Tammy Kielian   +3 more
doaj   +2 more sources

Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10 [PDF]

Viruses, 2018
Inflammatory bowel disease (IBD) and Clostridium difficile infection cause gastrointestinal (GI) distension and, in severe cases, toxic megacolon with risk of perforation and death. Herpesviruses have been linked to severe GI dilatation.
Hao Chen, Mee Yong Bartee, Jordan R. Yaron, Liying Liu, Liqiang Zhang, Donghang Zheng, Ian B. Hogue, Whitney L. Bullard, Scott Tibbetts, Alexandra R. Lucas   +9 more
doaj   +2 more sources

Case report: IL12RB1 deficiency in an infant with disseminated Bacille Calmette-Guérin disease [PDF]

Frontiers in Immunology
Disseminated Bacille Calmette-Guérin (BCG) disease is a rare adverse reaction to BCG vaccination. We report a neonate presenting with a progressive left axillary mass 3 months post-vaccination.
Xiao Ma, Juping Chen, Junqiao Cheng, Jingbo Wang   +3 more
doaj   +2 more sources