Results 41 to 50 of about 128,935 (252)

Nivolumab and interferon-γ rescue therapy to control mixed mould and bacterial superinfection after necrotizing fasciitis and septic shock

Medical Mycology Case Reports, 2022
Immunosuppression is a major feature of septic shock and patients are at increased risk for opportunistic infections. We describe a successful use of immunostimulation to treat mixed mould and bacterial superinfection in a previously healthy 38-year-old ...
Anne-Claire Lukaszewicz, Fabienne Venet, André Boibieux, Mathilde Lherm, Bertrand Devigne, Guillaume Monneret   +5 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Interferon-γ and tumor growth

Сибирский онкологический журнал, 2023
Purpose of the study: to analyze published data on the mechanisms of action of interferon gamma (IFN-γ) in tumor growth and to evaluate the possibility of its use in the treatment of solid tumors. Material and Methods.
A. L. Ilyushin, I. V. Bogdashin, A. Z. Aleksanyan, V. V. Novikov, L. A. Ashrafyan   +4 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

BCG DISSEMINATION IN 40 PATIENTS AND THE REVIEW OF "LEUKOCYTE MYCOBACTERIUM DEFECT" IN ONE PATIENT

Iranian Journal of Allergy, Asthma and Immunology, 2000
We have reviewed the medical records of 40 patients with disseminated (Bacille Calmette-Guerin) BCG from 1996 to 1999 in the Immunology Department of the Children Hospital, Medical Center, Tehran university.
A. Farhondi, N. Barzargan, S. Arshi Z. Pourpak   +2 more
doaj  

The synergistic effect of human recombinant interferon-.ALPHA.2a in combination with interferon-.GAMMA. and the induction of interferon-.ALPHA.2a receptor by interferon-.GAMMA..

Journal of Pharmacobio-Dynamics, 1989
An in vitro examination was made of the synergistic antiproliferative effect of recombinant interferon-gamma (IFN-gamma) with interferon-alpha 2a (IFN-alpha 2a) on human tumor cell lines, including lung small cell carcinoma QG-90, amelanotic melanoma HMV-1, renal carcinoma ACHN and Burkitt lymphoma Daudi.
ISHII, Yoshiaki, TSUKAGOSHI, Shigeru
openaire   +3 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

eLife, 2018
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses.
Tonya Kueck, Elena Cassella, Jessica Holler, Baek Kim, Paul D Bieniasz   +4 more
doaj   +1 more source

Normal expression of IFN-gammaR in four patients with uncommon mycobacterial infection phenotypes [PDF]

Brazilian Journal of Medical and Biological Research, 2004
Several primary immunodeficiency diseases affecting the interleukin 12/interferon gamma (IFN-gamma) pathway have been identified, most of them characterized by recurrent and protracted infections produced by intracellular microorganisms, particularly by ...
M.T. Rugeles, B. Rincón, C. Rugeles, C.J. Montoya, M. Hernández, C. Estrada, M.M. Olivares, P.J. Patiño   +7 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source