Results 11 to 20 of about 128,935 (252)

Successful treatment of invasive mycobacterium infection with interferon beta in a patient with Interferon-Gamma Receptor 1 deficiency

Journal of Infection and Public Health
Mendelian susceptibility to mycobacterial disease (MSMD) is caused by approximately 21 genetic defects, including a mutation in Interferon-Gamma Receptor 1 (IFNGR1).
Fayhan Alroqi, Abduarahman Almutairi, Moza Alhammadi, Shatha Alhamdi   +3 more
doaj   +3 more sources

Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size

iScience, 2022
Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong, Lu Lu, Lin-Lei Chen, Man-Lung Yeung, Anna Jinxia Zhang, Hanjun Zhao, Kwok-Yung Yuen, Kelvin Kai-Wang To   +7 more
doaj   +1 more source

Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. [PDF]

PLoS ONE, 2007
BACKGROUND: Host innate immunity contributes to malaria clinical outcome by providing protective inflammatory cytokines such as interferon-gamma, and by shaping the adaptive immune response.
Myriam Baratin, Sophie Roetynck, Bruno Pouvelle, Céline Lemmers, Nicola K Viebig, Sofia Johansson, Philippe Bierling, Artur Scherf, Jürg Gysin, Eric Vivier, Sophie Ugolini   +10 more
doaj   +1 more source

Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population

The Turkish Journal of Gastroenterology, 2020
Background and Aims: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence
Zahra Heidari, Bita Moudi, Hamidreza Mahmoudzadeh-Sagheb   +2 more
doaj   +1 more source

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion

Journal of Neuroinflammation, 2018
Background The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a
Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo, Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker   +8 more
doaj   +1 more source

IFN-γR2 is strongly expressed on endothelial cells of gingival tissues from patients with chronic periodontitis

Journal of Applied Oral Science, 2018
Chronic periodontitis (CP) is characterized by gingival inflammation and bone destruction. It has been reported that interferon-gamma (IFN-γ) levels are high in CP patients; however, the IFN-γ receptor (IFN-γR) has not been studied in gingival tissue ...
Ramón Franco-Topete, José Sergio Zepeda-Nuño, Ana Lourdes Zamora-Perez, Martha Graciela Fuentes-Lerma, Belinda Claudia Gómez-Meda, Celia Guerrero-Velázquez   +5 more
doaj   +1 more source

New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics

Scientific Reports, 2021
In this investigation, we report the effect on the microscopic dynamics and interactions of the cytokine interferon gamma (IFN-γ) and antibodies to IFN-γ (anti-IFN-γ) and to the interferon gamma receptor 1 (anti-IFNGR1) prepared in exceptionally dilute ...
Kristina N. Woods
doaj   +1 more source

One interferon gamma receptor binds one interferon gamma dimer.

Journal of Biological Chemistry, 1990
We investigated the stoichiometry of the interferon gamma and interferon gamma receptor interaction, using recombinant interferon gamma and recombinant soluble interferon gamma receptor, applying chemical cross-linking and chromatographic techniques, and analyzing the resulting products in denaturing polyacrylamide gels.
M, Fountoulakis, J F, Juranville, A, Maris, L, Ozmen, G, Garotta   +4 more
openaire   +2 more sources

BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. [PDF]

PLoS Biology, 2007
Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lacking ...
Wei Cao, Li Zhang, David B Rosen, Laura Bover, Gokuran Watanabe, Musheng Bao, Lewis L Lanier, Yong-Jun Liu   +7 more
doaj   +1 more source

Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis.

PLoS ONE, 2013
Interferon (IFN)-gamma is an important component of the immune response to viral infections that can have a role both in controlling virus replication and inducing inflammatory damage.
Eun-Young Lee, Kimberly L W Schultz, Diane E Griffin   +2 more
doaj   +1 more source