Results 131 to 140 of about 260,978 (210)

Lambda Corporation report on the Lambda Data Management System

open access: yes, 1970
Hugh Everett III invented the first relational database-type program. It was used by Lambda and American Management Systems (which hired Everett) in business applications.
Everett, Hugh
core  

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 49, 3 September 2026.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu   +17 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

open access: yesAdvanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu   +6 more
wiley   +1 more source

UA12/2/74 Lambda Times, Vol. 1, Issue 1 [PDF]

open access: yes, 1999
Newsletter created by and about the Lambda Society. Articles: Leffler, Matthew. Louisville\u27s First Circuit Party Draws Hundreds James, Elizabeth. WKU Lambda to Host Faculty & Staff Dinner Lockhart, Shaun.
Lambda Society
core  

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu   +8 more
wiley   +1 more source

Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study.

open access: yes, 1998
BACKGROUND: There is debate about whether interferon-alpha treatment lowers the risk of progression to hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis and whether any effect is limited to certain subgroups. We investigated
(INTERNATIONAL HEPATOCELLULAR CARCINOMA STUDY GROUP   +3 more
core  

Gradually Enlarging Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome

open access: yesRespirology Case Reports, Volume 14, Issue 9, September 2026.
A woman with Sjögren's syndrome presented with progressively enlarging pulmonary nodules showing calcification and cystic changes, mimicking metastatic malignancy. Histological examination confirmed AL λ‐type nodular pulmonary amyloidosis. Recognition of this radiological pattern is important to avoid misdiagnosis and unnecessary invasive interventions.
Noboru Morikawa   +2 more
wiley   +1 more source

Porcine interferon-alpha but not interferon-lambda inhibits replication of genotypically diverse PRRSV isolates in vitro

open access: yesFrontiers in Veterinary Science
IntroductionPorcine reproductive and respiratory syndrome (PRRS) is an economically devastating viral infection in pigs that results in estimated losses of $1.2 billion annually.
Samantha J. Hau   +5 more
doaj   +1 more source

LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
We present LivAge, an online aging clock that estimates murine transcriptomic age from hepatic RNA‐seq data. Externally validated, it detects accelerated aging in progeroid models and quantifies the effect of geroprotective interventions, providing an accurate, accessible, and ready‐to‐use tool for aging research.
Víctor Celemín‐Capaldi   +6 more
wiley   +1 more source

The Interferon-Lambda Family Celebrates 20 Years of Scientific Discovery. [PDF]

open access: yesJ Interferon Cytokine Res, 2023
Donnelly RP, Prokunina-Olsson L.
europepmc   +1 more source

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