Results 71 to 80 of about 118,218,999 (286)
A hyperactive mutant of interferon-regulatory factor 4
, 2022 We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4.Hartmann, Enno, Porapu, Alekya, Lohoff, Michael, Menke, Lisa, Pinkenburg, Olaf, Raifer, H, Camara, B, Bieringer, Maria, Kang, Chol-Ho, Staudenraus, Daniel, Abass, E, Bruestle, Anne +11 morecore +1 more sourceInterleukin-18 [PDF]
, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.McInnes, I.B., Robertson, S.E., Gracie, J.A. +2 morecore +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceBunyaviruses and the type I interferon system [PDF]
, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as Richard M. Elliott, Weber, F., Richard Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M. +6 morecore +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceGenome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer
Frontiers in Cell and Developmental BiologyIntroductionProgrammed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration.Wenxuan Fu, Wenxuan Fu, Xiaomeng Chang, Xiaomeng Chang, Xiaomeng Chang, Kun Ye, Kun Ye, Zige Zheng, Zige Zheng, Qianyi Lai, Qianyi Lai, Minyang Ge, Minyang Ge, Yan Shi, Yan Shi, Yan Shi +15 moredoaj +1 more sourceThe systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis [PDF]
, 2013 Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory ...Schuerwegh, A. J., Alexander Kreuter (592), Herrick Ariane, Martín J., Carmona, F.D., Jacob M van Laar, Madelon C Vonk, Voskuyl AE, Denton C, Mónica Fernández-Castro, Martin Jose-Ezequiel, Hunzelmann Nicolas, Airó Paolo, Ariane Herrick (214049), Claudio Lunardi (12868), Paul Shiels (276244), Witte, T. de, Voskuyl Alexandre E., Distler, J.H., Riemekasten, Gabriela, H W Distler, Egurbide, María Victoria, Mónica Fernández-Castro (276238), Radstake TR, Camps, M.T., Egurbide, M. V., Simeón, C.P., Carreira, Patricia E., Airó, P., Kreuter, Alexander, Camps María Teresa, Airó, Paolo, Scorza, Raffaella, Martín, Javier, the Spanish Scleroderma Group, Nicolas Hunzelmann, Beltrán Emma, Madelon C. Vonk (213950), Torsten Witte, Javier Martín (2584444), Sáez-Comet, Luis, van Laar, J.M., María Teresa Camps, Callejas, J.L., Carmen Fonseca (214061), Airó P, Martin, J.E., Madhok, Rajan, Fernández Castro M, Kreuter, A., Herrick A, Carmen P. Simeón (5650816), Riemekasten Gabriela, Beltrán E, Radstake, T. R., Shiels, Paul G., Alexandre E. Voskuyl (213961), Carreira, P.E., Vonk, M.C., Lorenzo Beretta, Carreira PE, Hunzelmann N, Kreuter A, Patricia E. Carreira (276236), Beltrán, Emma, Carmona F. David, Rajan Madhok, Worthington J, Gabriela Riemekasten, Scorza R, Vonk MC, Simeón Carmen P., Witte, Torsten, Camps, María Teresa, Carmona FD, Herrick, A., Schuerwegh AJ, Paolo Airó, Distler, Jörg H W, Radstake Timothy R. D. J., Alexandre E Voskuyl, et al., José Luis Callejas (276237), Schuerwegh, Annemie J, Jane Worthington, Laar, Jacob M. van, Madhok R, Callejas, José Luis, Martín, J. E., Jacob M. van Laar (177818), Vonk Madelon C., Javier Martín, Beretta, Lorenzo, Emma Beltrá, Timothy R. D. J. Radstake (168224), Shiels Paul, Jörg H. W. Distler (3196062), Madhok Rajan, Callejas JL, Beltrán, E., Martin, Jose Ezequiel, Schuerwegh, A.J., Witte Torsten, Distler, J.H. W., Raffaella Scorza, Voskuyl, Alexandre E., Carmen P Simeón, Carmona, F David, Spanish Scleroderma, Claudio Lunardi, Rajan Madhok (23535), Group ", Voskuyl, A.E., Worthington, Jane, Egurbide, M.V., Jörg H W Distler, Saez-Comet, L., Callejas-Rubio, José Luis, Voskuyl, Alexandre E, van Laar JM, Simeón, Carmen P., Gabriela Riemekasten (276243), Denton, Christopher, Schuerwegh Annemie J., Camps MT, Paolo Airó (5650819), Witte T, Carmona, Francisco David, Denton, C., Lunardi, C., Fernández-Castro Mónica, Simeón, Carmen P, Riemekasten G, Luis Sáez-Comet (276239), Fonseca Carmen, Fernández-Castro, M., Herrick, Ariane, Timothy R D J Radstake, Scorza, R., Madhok, R., Denton Christopher, Fonseca, Carmen, Beretta L, Christopher Denton, Luis Sá Ez-Comet, Worthington, J., José Luis Callejas, Beretta, L., Annemie J Schuerwegh, Kreuter Alexander, Simeón CP, Nicolas Hunzelmann (213980), Lunardi Claudio, Jane Worthington (23502), Torsten Witte (32240), Emma Beltrán (276240), Lunardi, Claudio, Shiels, P., Carreira Patricia E., Fonseca C, Sáez Comet L, Shiels, Paul, Martín, J., Carmen Fonseca, F. David Carmona (276235), Riemekasten, G., Witte, T., Luis Sáez-Comet, Radstake, Timothy R. D. J., Jö Rg, van Laar, Jacob M., Egurbide María Victoria, Fernández-Castro, Monica, Radstake, T.R.D.J., van Laar Jacob M., Ariane Herrick, Emma Beltrán, Christopher Denton (276245), Alexander Kreuter, Martín Javier, Mó Nica Ferná Ndez-Castro, Shiels P, Vonk, Madelon C, Carreira, Patricia E, Fonseca, C., Paul Shiels, Callejas José Luis, Carmen P Simeó N, Martin JE, Lorenzo Beretta (214056), Egurbide MV, Distler Jörg H. W., Raffaella Scorza (214013), Vonk, Madelon C., María Victoria Egurbide, Hunzelmann, Nicolas, Carmona, F. David, Schuerwegh, Annemie J., Jose-Ezequiel Martin, Beretta Lorenzo, Patricia E Carreira, María Teresa Camps (276241), Scorza Raffaella, Annemie J. Schuerwegh (213966), Sáez-Comet Luis, F David Carmona, María Victoria Egurbide (276242), Laar, J.M. van, Hunzelmann, N., Worthington Jane, Martin, Jose-Ezequiel, van Laar, Jacob M, Spanish Scleroderma Group, Jose-Ezequiel Martin (213926), Distler JH, Radstake, Timothy R D J, Distler, Jörg H. W., Camps, Teresa +217 morecore +1 more source
