Results 51 to 60 of about 118,218,999 (286)

Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1 [PDF]

Journal of Virology, 2004
ABSTRACT Cellular antiviral responses are mediated partly by the expression of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative intermediates. Persistent replication of a hepatitis C virus (HCV) replicon suggests that the replicon does not elicit cellular innate antiviral responses.
Nobuhiko, Kanazawa, Masayuki, Kurosaki, Naoya, Sakamoto, Nobuyuki, Enomoto, Yasuhiro, Itsui, Tsuyoshi, Yamashiro, Yoko, Tanabe, Shinya, Maekawa, Mina, Nakagawa, Cheng-Hsin, Chen, Sei, Kakinuma, Shigeru, Oshima, Tetsuya, Nakamura, Takanobu, Kato, Takaji, Wakita, Mamoru, Watanabe   +15 more
openaire   +2 more sources

Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape [PDF]

, 2003
Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1
Bossert, Birgit
core   +1 more source

Identification of the DNA sequence interacting with Kaposis sarcoma-associated herpesvirus viral interferon regulatory factor 1 [PDF]

, 2007
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal ...
Yoo, Seung-Min, Lee, Daeyoup, Lee, Myung-Shin, Jeong, Kwi Wan, Choe, Joonho, Seo, Taegun, Park, Junsoo   +6 more
core   +1 more source

Molecular characterization of interferon regulatory factor 1 in Bubalus bubalis

Genetics and Molecular Research, 2015
Interferon regulatory factor 1 (IRF1) is functionally diverse in the regulation of immune response and is considered to be an important candidate gene for studying disease susceptibility in mammals. In this paper, we characterized the whole sequence of the IRF1 gene in river buffalo (Bubalus bubalis) and compared genomic and the amino acid sequences ...
Stafuzza, N. B., Borges, M. M., Amaral-Trusty, M. E. J.   +2 more
openaire   +3 more sources

17β-Estradiol downregulates interferon regulatory factor-1 in murine splenocytes [PDF]

Journal of Molecular Endocrinology, 2006
Abstract Interferon regulatory factor-1 (IRF-1) is an important transcription factor that mediates interferon-γ (IFN-γ)-induced cell-signaling events. In this study, we examined whether 17β-estradiol alters IRF-1 in splenic lymphocytes, in view of the immunomodulatory effects of this natural female sex hormone including its ability to
Andrea J, Lengi, Rebecca A, Phillips, Ebru, Karpuzoglu, Sattar Ansar, Ahmed   +3 more
openaire   +2 more sources

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon
Hindle, Laura, L. M. Butler, K. Shah, Hindle, L, Lowry, K, S. A. Chanas, Mutocheluh, Mohamed, K. Lowry, Lowry, K., Shah, K., Chanas, Simon, Chanas, SA, D. J. Blackbourn, Areste, C., M. Mutocheluh, Aresté, C, Butler, Lucilla, Butler, LM, Shah, K, Blackbourn, DJ, L. Hindle, Blackbourn, David, C. Aresté, Chanas, S. A., Lowry, Kym, Mutocheluh, M, Blackbourn, D. J., Mutocheluh, M., Evans, DJ, Evans, David J., D. J. Evans, Hindle, L., Evans, D. J., Butler, L. M., Evans, D. J.; id_orcid   +34 more
core   +2 more sources

A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia [PDF]

Human Molecular Genetics, 2003
Neointima formation, the leading cause of restenosis after catheter angioplasty, is a paradigm for vascular proliferative responses. Neointima formation is self-limiting after a variable degree of tissue growth, causing significant renarrowing in a substantial number of patients.
Wessely, R., Hengst, L., Jaschke, B., Wegener, F., Richter, T., Lupetti, R., Paschalidis, M., Schomig, A., Brandl, R., Neumann, F.   +9 more
openaire   +3 more sources

MiR-23a facilitates the replication of HSV-1 through the suppression of interferon regulatory factor 1.

PLoS ONE, 2014
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression. It has been reported that miRNAs are involved in host-virus interaction, but evidence that cellular miRNAs promote virus replication has been limited.
Jing Ru, Huahui Sun, Hongxia Fan, Chunmei Wang, Yixuan Li, Min Liu, Hua Tang   +6 more
doaj   +1 more source

Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Journal of Ginseng Research, 2017
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects ...
Tao Yu, Yanyan Yang, Yi-Seong Kwak, Gwan Gyu Song, Mi-Yeon Kim, Man Hee Rhee, Jae Youl Cho   +6 more
doaj   +1 more source

miR-23a targets interferon regulatory factor 1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric adenocarcinoma cells. [PDF]

PLoS ONE, 2013
MicroRNAs are a class of non-coding RNAs that function as key regulators of gene expression at the post-transcriptional level. In our previous research, we found that miR-23a was significantly up-regulated in human gastric adenocarcinoma cells.
Xue Liu, Jing Ru, Jian Zhang, Li-hua Zhu, Min Liu, Xin Li, Hua Tang   +6 more
doaj   +1 more source