Current Issues in Molecular Biology, 2021 Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that negatively regulates anti-tumor immunity. Recent reports indicate that anti-cancer treatments, such as radiation therapy, increase PD-L1 expression on the surface of tumor cells.
Hironori Yoshino +2 more
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Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]
, 2008 Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat +7 more
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Ad-IRF-1 Induces Apoptosis in Esophageal Adenocarcinoma
Neoplasia: An International Journal for Oncology Research, 2006 The nuclear transcription factor interferon regulatory factor-1 (IRF-1) is a putative tumor suppressor, but the expression and function of IRF-1 in esophageal adenocarcinoma (EA) remain unknown.
Gregory A. Watson +7 more
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Interferon Regulatory Factor-1, Interferon-β, and Reovirus-Induced Myocarditis
Virology, 2002 Viral myocarditis is an important human disease, and reovirus-induced myocarditis in mice provides an excellent model to study direct viral damage to the heart. Previously, we showed that reovirus induction of and sensitivity to interferon-beta (IFN-beta) is an important determinant of viral pathogenicity in the heart and that the transcription factor ...
Azzam-Smoak, Kathleen +4 more
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Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1 [PDF]
Blood, 1995 Biologic responses to cytokines are mediated by intracellular pathways involving induction of signaling and metabolic cascades. Interferon (IFN) regulatory factor-1 (IRF-1) is a major transcription factor induced not only by IFN-gamma but also by other cytokines including tumor necrosis factor-alpha (TNF-alpha). Possible IRF-1 binding sequence elements
Sato T +3 more
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Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
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Brazilian Archives of Biology and Technology, 2017 IFN-γ (Interferon-gamma), Mx and IRF-1 (Interferon regulatory factor-1) are main immune-related genes and they play important roles in the innate immune system of vertebrates.
Feng Zhang +5 more
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Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN
Frontiers in Immunology, 2021 The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory factors (IRFs).
Simon Loevenich +6 more
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CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]
, 2010 Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA +23 more
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Antiviral Activity of Porcine Interferon Regulatory Factor 1 against Swine Viruses in Cell Culture
Viruses, 2015 Interferon regulatory factor 1 (IRF1), as an important transcription factor, is abundantly induced upon virus infections and participates in host antiviral immune responses.
Yongtao Li +8 more
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