Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. [PDF]
JCI Insight, 2020 Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers.
Karki R +10 more
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Sequential Interferon β-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner [PDF]
Biomolecules, 2020 Immunogenic cell death (ICD) refers to a unique form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Accumulating evidence indicates that the efficacy of conventional anticancer agents relies on not only ...
Pei-Ming Yang +4 more
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Correction: Expression of Concern: MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1 [PDF]
PLoS ONE, 2022 The Editors
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Expression of Concern: MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1. [PDF]
PLoS ONE, 2020 PLOS ONE Editors
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SPOP targets the immune transcription factor IRF1 for proteasomal degradation
eLife, 2023 Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon regulatory factor 1 (IRF1)
Irene Schwartz +14 more
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Interferon Regulatory Factor 1 in Mycobacterial Infection [PDF]
Microbiology and Immunology, 2002 AbstractIn order to understand the role of IRF‐1 in the development of murine tuberculosis in vivo, IRF‐1 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. These knockout mice developed multifocal necrotic lesions in the lung, liver and spleen tissues and died of ...
Hiroyuki, Yamada +2 more
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Interferon regulatory factor 1 induces the expression of the interferon‐stimulated genes [PDF]
British Journal of Haematology, 1997 The interferon regulatory factor 1 (IRF‐1) is a positive transcriptional regulatory protein which acts in the interferon signal transduction pathway to activate the transcription of the type I interferon genes by binding to the PRDI response element. The aim of this study was to explore the role of IRF‐1 in regulating the expression of other interferon‐
Y C, Henderson, M, Chou, A B, Deisseroth
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Role of interferon regulatory factor 1 in monocyte/macrophage differentiation [PDF]
European Journal of Immunology, 1999 Interferon regulatory factor-1 (IRF-1) has been recognized as an important tumor suppressor and growth regulatory transcription factor, which is also involved in cell differentiation. In this study we investigated the role of IRF-1 in phorbol 12-myristate 13-acetate (PMA)-induced monocyte/macrophage differentiation of human monoblastic U937 cells.
MANZELLA, LIVIA +7 more
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Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2 [PDF]
British Journal of Cancer, 1998 Transcriptional activator interferon regulatory factor (IRF)-1 and repressor IRF-2 are known to play a critical role in the regulation of interferon (IFN) responses and oncogenesis in fibroblasts. Although these two factors are expressed in many tissues, including the brain, the role of IRFs in the central nervous system (CNS) has not been elucidated ...
K C, Park +3 more
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Interferon regulatory factor 7 in inflammation, cancer and infection [PDF]
, 2023 Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-
Furong Qing, Zhiping Liu
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