Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1 [PDF]
Autophagy Reports, 2023 Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
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Molecular characterization and antiviral effects of canine interferon regulatory factor 1 (CaIRF1) [PDF]
BMC Veterinary Research, 2022 Background Interferon regulatory factor 1 (IRF1) is an important transcription factor that activates the type I interferon (IFN-I) response and plays a vital role in the antiviral immune response.
Xiangqi Hao +7 more
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Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1). [PDF]
PLoS Pathogens, 2023 Post-translational modifications (PTMs) are essential for host antiviral immune response and viral immune evasion. Among a set of novel acylations, lysine propionylation (Kpr) has been detected in both histone and non-histone proteins.
Jiale Shi +8 more
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Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses. [PDF]
PLoS Pathogens, 2021 The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes.
Hui Feng +4 more
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Interferon regulatory factor 1 enhances T cell differentiation in patients with myasthenia gravis [PDF]
Neural Regeneration ResearchInterferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis. However, its function in myasthenia gravis remains unclear.
Yuebei Luo +5 more
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Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1 [PDF]
Frontiers in ImmunologyIntroductionUltraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I interferons (IFNs) that promote increased keratinocyte (KC) death after UV ...
Shannon N. Loftus +11 more
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Ataxin-10 Inhibits TNF-α-Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1 [PDF]
Mediators of Inflammation, 2021 Endothelial inflammation is a crucial event in the initiation of atherosclerosis. Here, we identify Ataxin-10 protein as a novel negative modulator of endothelial activation by suppressing IRF-1 transcription activity.
Yong Li +7 more
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Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection [PDF]
Nature Communications, 2022 Innate lymphoid cells (ILC) are involved with different immune responses. Here the authors show that Interferon regulatory factor 1 (IRF1) is important for intestinal ILC3 accumulation during Citrobacter rodentium infection and promotes release of the ...
Angelika Schmalzl +7 more
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Vascular smooth muscle cell-derived SO2 sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence [PDF]
Frontiers in PharmacologyBackgroundVascular smooth muscle cell (VSMC) senescence is a critical driver of vascular aging and various age-related cardiovascular diseases. Endogenous sulfur dioxide (SO2), a newly identified key cardiovascular gaseous signaling mediator, accelerates
Bingquan Qiu +12 more
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Clinical significance and biological function of interferon regulatory factor 1 in non-small cell lung cancer [PDF]
Frontiers in PharmacologyThe clinical application and biological function of interferon regulatory factor 1 (IRF1) in non-small cell lung cancer (NSCLC) patients undergoing chemoimmunotherapy remain elusive.
Jialin Su +10 more
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