Results 31 to 40 of about 118,218,999 (286)

Identification of Proteins Immunologically Related to Interferon Regulatory Factor–1 That Bind with Interferon Regulatory Factor Element [PDF]

The Journal of Infectious Diseases, 2006
Interferon regulatory factor (IRF)-1 expression was surveyed in nontransformed and oncogene-transformed mouse fibroblasts, using Western immunoblot with an IRF-1-specific antiserum, to examine possible differences resulting from cellular transformation. Ten additional proteins that reacted with the IRF-1 antibody and that underwent specific competition
Sara, Contente, Frank A, Attard, Robert M, Friedman   +2 more
openaire   +2 more sources

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.), Sadik, Christian David, Bachmann, Malte, Mühl, Heiko   +3 more
core   +1 more source

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. [PDF]

PLoS ONE, 2016
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an ...
Aravind Tallam, Thaneer M Perumal, Paul M Antony, Christian Jäger, Joëlle V Fritz, Laurent Vallar, Rudi Balling, Antonio Del Sol, Alessandro Michelucci   +8 more
doaj   +1 more source

Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection [PDF]

, 2012
Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE).
Yamaguchi, Naohiro, Satoh, Katsuya, Fuse, Takayuki, Nishida, Noriyuki, Ishibashi, Daisuke, Atarashi, Ryuichiro, Nakagaki, Takehiro, Honda, Kenya   +7 more
core   +1 more source

DHAV-1 Blocks the Signaling Pathway Upstream of Type I Interferon by Inhibiting the Interferon Regulatory Factor 7 Protein

Frontiers in Microbiology, 2021
Duck hepatitis A virus (DHAV), which mainly infects 1- to 4-week-old ducklings, has a fatality rate of 95% and poses a huge economic threat to the duck industry. However, the mechanism by which DHAV-1 regulates the immune response of host cells is rarely
Yalan Lai, Yalan Lai, Yalan Lai, Xiaoyan Xia, Xiaoyan Xia, Xiaoyan Xia, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Di Sun, Di Sun, Di Sun, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Xin-Xin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Bin Tian, Bin Tian, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Leichang Pan, Leichang Pan   +62 more
doaj   +1 more source

Impaired myelopoiesis in mice devoid of interferon regulatory factor 1 [PDF]

Leukemia, 2004
Interferon regulatory factor (IRF)-1 is a transcription factor controlling the expression of several genes, which are differentially induced depending on the cell type and signal. IRF-1 modulates multiple functions, including regulation of immune responses and host defence, cell growth, cytokine signalling and hematopoietic development.
U. Testa, E. Stellacci, E. Pelosi, P. Sestili, VENDITTI, Mario, R. Orsatti, A. Fragale, E. Petrucci, L. Pasquini, F. Belardelli, L. Gabriele, A. Battistini   +11 more
openaire   +4 more sources

IRF4 (interferon regulatory factor 4) [PDF]

, 2009
Review on IRF4 (interferon regulatory factor 4), with data on DNA, on the protein encoded, and where the gene is ...
Rasi, S, Gaidano, G
core   +1 more source

Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1.

PLoS ONE, 2012
BackgroundInterferon-induced 35-kDa protein (IFP35) plays important roles in antiviral defense and the progression of some skin cancer diseases. It can be induced by interferon-γ (IFN-γ) in multiple human cells.
Wei Yang, Juan Tan, Ruikang Liu, Xiaoxu Cui, Qinglin Ma, Yunqi Geng, Wentao Qiao   +6 more
doaj   +1 more source

Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection

Scientific Reports, 2021
Viral infections of the cornea including herpes simplex virus 1 (HSV-1) cause visual morbidity, and the corneal endothelial cell damage leads to significant visual impairment.
Fumie Ohtani, Dai Miyazaki, Yumiko Shimizu, Tomoko Haruki, Satoru Yamagami, Yoshitsugu Inoue   +5 more
doaj   +1 more source