Results 131 to 140 of about 22,805,379 (236)

Emergence of macroscopic simplicity from the Tumor Necrosis Factor-alpha signaling dynamics [PDF]

, 2011
The Tumor Necrosis Factor-α (TNF-α), a cytokine produced during the innate immune response to invading pathogens, is involved in numerous fundamental cellular processes.
Vincent Piras, Kumar Selvarajoo, Masaru Tomita, Kentaro Hayashi, Masa Tsuchiya   +4 more
core  

Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation

Cell Communication and Signaling
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid blasts. In this study, we investigated the role of interferon regulatory factor 3 (IRF3), a key transcription factor of type I interferon, in AML differentiation.
Manman Geng, Aili He, Qiaoyan Jin, Dongxia Liang, Xiaoyu Ren, Xiaomeng Li, Yanglong Guan, Chongyu Zhang, Yaqi Lu, Jing Zhang, Wentao Zhang, Yuanyuan Cheng, Yingnan Li, Yuanshuo Ouyang, Kewei Chang, Liesu Meng, Wenhua Zhu, Shemin Lu   +17 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Vaccinia Virus Expressing Interferon Regulatory Factor 3 Induces Higher Protective Immune Responses against Lethal Poxvirus Challenge in Atopic Organism. [PDF]

Viruses, 2021
Pilna H, Hajkova V, Knitlova J, Liskova J, Elsterova J, Melkova Z.   +5 more
europepmc   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Investigation of interferon regulatory factor, interferon alpha and beta levels in patients with Familial Mediterranean Fever

, 2023
Tıp Fakültesi, İç Hastalıkları Ana Bilim DalıAilevi Akdeniz Ateşi (AAA, Familial Mediterraean Fever; FMF) periyodik ateş ve serozal inflamasyon ile karakterize ataklarla kendini gösteren otoinflamatuar bir hastalıktır.
Kelici, Melike Yerliyurt
core  

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus [PDF]

, 1996
The myosin light-chain 1/3 locus (MLC1/3) is regulated by two promoters and a downstream enhancer element which produce two protein isoforms in fast skeletal muscle at distinct stages of mouse embryogenesis. We have analyzed the expression of transcripts
McGrew, M J; id_orcid, Hasegawa, K, Bogdanova, N, Kitsis, R N, Rosenthal, N, Hughes, S H   +5 more
core  

Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus. [PDF]

Viruses, 2021
Glanz A, Chakravarty S, Varghese M, Kottapalli A, Fan S, Chakravarti R, Chattopadhyay S.   +6 more
europepmc   +1 more source