Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
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Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
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Bunyaviruses and the type I interferon system [PDF]
, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott +7 more
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The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism [PDF]
, 2010 This work is supported by UK MRC and BBRCBunyamwera virus NSs protein is involved in the inhibition of cellular transcription and the interferon (IFN) response, and it interacts with the Med8 component of Mediator.
Van Knippenberg, Ingeborg Christine +5 more
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Protective Role of the Host Innate Immune System in Prion Pathogenesis [PDF]
, 2019 Prion diseases, including human Creutzfeldt-Jakob disease, are infectious, intractable central neurodegenerative diseases, which are also zoonoses that commonly infect not only higher organisms but also a wide variety of animals.Pathogenic prions induce
石橋, 大輔
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Interferon regulatory factor 3 in adaptive immune responses. [PDF]
Cell Mol Life Sci, 2014 Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells.
Ysebrant de Lendonck L +2 more
europepmc +2 more sources
Upregulated Expression of Runt-related Transcription Factor 3 and Interferon Regulatory Factor 4 Genes in Patients With Ankylosing Spondylitis [PDF]
Research in Molecular Medicine, 2022 Background: Ankylosing spondylitis (AS) is a debilitating autoimmune disease presented by chronic inflammation of large joints and central skeleton. The role of various immune cells, including T cell subsets, has been studied in the pathogenesis of AS ...
Sara Assadiasl +7 more
doaj
Impact of interferon β and interferon stimulated gene induction on Bunyamwera virus replication [PDF]
, 2012 The first line of defence against viral infection is the interferon (IFN) response, which must be overcome by a virus for successful replication. Pattern recognition receptors detect virus which triggers induction of IFNβ.
Carlton-Smith, Charles
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Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape [PDF]
, 2003 Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1
Bossert, Birgit
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Activation and modulation of antiviral and apoptotic genes in pigs infected with classical swine fever viruses of high, moderate or low virulence [PDF]
, 2009 The immune response to CSFV and the strategies of this virus to evade and suppress the pigs’ immune system are still poorly understood. Therefore, we investigated the transcriptional response in the tonsils, median retropharyngeal lymph node (MRLN), and ...
Hulst, M.M. +10 more
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