Results 251 to 260 of about 9,208,925 (289)

PTEN restricts infectious bursal disease virus replication through modulating the AKT-TBK1-mediated type I IFN pathway. [PDF]

Poult Sci
Wang M, Yu Y, Liu G, Cheng L, Li B, Gao P, Tang H, Xu Z, Ma J.   +8 more
europepmc   +1 more source

Interferon Regulatory Factor 9 Structure and Regulation [PDF]

Frontiers in Immunology, 2018
Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has just begun to emerge.
Thean-Hock Tang, Siew Kit Ng
exaly   +6 more sources

Roles of Interferon-Regulatory Factors in T-Helper-Cell Differentiation

Nature Reviews Immunology, 2005
Members of the interferon-regulatory factor family of transcription factors have long been known to be intracellular mediators of the effects of interferons. In recent years, interferon-regulatory factors have also been shown to have an essential role in
Tak W Mak, Michael Lohoff
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Interferon Regulatory Factors: The Next Generation

Gene, 1999
Interferons are a large family of multifunctional secreted proteins involved in antiviral defense, cell growth regulation and immune activation. Viral infection induces transcription of multiple IFN genes, a response that is in part mediated by the interferon regulatory factors (IRFs). The initially characterized members IRF-1 and IRF-2 are now part of
Rongtuan Lin, Marc J Servant, John Hiscott   +2 more
exaly   +3 more sources

The interferon regulatory factors and oncogenesis

Seminars in Cancer Biology, 2000
We study a family of transcription factors, the interferon regulatory factors (IRFs), as originally identified in the context of the regulation of type-I interferon (IFN-alpha/beta) system. Most notably, studies on IRF-1 have revealed its remarkable functional diversity in the regulation of cellular responses of host defense, including oncogenesis. The
N, Tanaka, T, Taniguchi
openaire   +2 more sources

Role for Interferon Regulatory Factors in Autoimmunity

Joint Bone Spine, 2010
Interferon regulatory factors (IRFs) were first identified during studies of type I interferons. Since then, many investigations have established that IRFs are involved in regulating the innate immune response, the development of various immune cell types, and carcinogenesis.
Ian R Rifkin, Corinne Miceli-Richard, Christophe Richez   +2 more
exaly   +3 more sources

Interferon regulatory factor 6

2018
<p>Cutaneous wound healing is an inherent biological process to every injury, surgical procedure, and cases of trauma. Wound healing is loosely categorized into three overlapping phases: inflammation, epithelialization, and maturation.
Leah Christine Biggs, Martine Dunnwald, Jeff C. Murray, Douglas Houston, Prabhat Goswami, Aloysius Klingelhutz, Andrew Russo   +6 more
openaire   +1 more source

Interferon regulatory factors: Where to stand in transplantation

Transplant Immunology, 2018
Interferon regulatory factors (IRFs) are implicated in regulating inflammatory responses to pathogens and alloantigens. Since transplantation is usually accompanied by ischemia reperfusion injury (IRI), acute and chronic rejections, as well as immunodeficiency due to immunosuppressive drugs, IRFs seem to play a considerable role in allograft outcome ...
Sara, Assadiasl, Abbas, Shahi, Saeedeh, Salehi, Shima, Afzali, Aliakbar, Amirzargar   +4 more
openaire   +2 more sources

Interferon regulatory factor 5 polymorphisms in sarcoidosis

Modern Rheumatology, 2013
Interferon regulatory factor 5 (IRF5) gene polymorphisms are associated with susceptibility to autoimmune diseases. The aim of this study is to determine the roles of IRF5 single-nucleotide polymorphisms (SNPs) in sarcoidosis.A total of 175 Japanese patients with biopsy-proven sarcoidosis and 150 sex-matched controls were genotyped for four IRF5 SNPs ...
Kiminobu, Tanizawa, Tomohiro, Handa, Sonoko, Nagai, Hiroe, Sato, Ryo, Yamada, Isao, Ito, Takeshi, Kubo, Yutaka, Ito, Kizuku, Watanabe, Kensaku, Aihara, Kohei, Ikezoe, Michiaki, Mishima, Takateru, Izumi   +12 more
openaire   +2 more sources