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Interferon Regulatory Factor Signalings in Cardiometabolic Diseases
Hypertension, 2015Cardiometabolic diseases comprise a spectrum of interconnected pathological alterations in metabolic organs and in the cardiovascular system that occur alone or simultaneously.1 Although great efforts have been undertaken to develop therapeutic agents (eg, statins and tissue-type plasminogen activator) for these unfavorable conditions, epidemiological ...
Xiao-Jing, Zhang +2 more
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Interferon regulatory factors: A key to tumour immunity
International Immunopharmacology, 2017Interferon regulatory factors (IRFs), which have 10 members, belong to the transcription factor family and were named because of the regulation of interferon expression. They play important roles in the immune regulation, cell differentiation, cell apoptosis, and cell cycle regulation.
Yan-Jie, Chen +3 more
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A hyperactive mutant of interferon‐regulatory factor 4
European Journal of Immunology, 2018We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon-regulatory factor) C-terminus creates hyperactive IRF4. When introduced into IRF4-deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4.
Chol Ho Kang +11 more
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Interferon-Independent Protection by Interferon Regulatory Factor 3
The Journal of Immunology, 2018Abstract BACKGROUND Independent type I/III IFN regulation, interferon-regulatory factor 3 (IRF3) can mediate cell death and suppress proliferation during stress. Novel ‘suicide necrosis’ centers around IRF3 and is one protective mechanism against intracellular pathogens.
Clare Elise Gyorke, Uma Nagarajan
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Stimulation of interferon regulatory factor-1 by prolactin
Lupus, 2001Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse cellular functions including proliferation, differentiation, angiogenesis and protection against apoptosis and inflammation. To understand the mechanism of PRL signaling in T cells, we have cloned both PRL and its receptor (PRL-R), one potent mediator of PRL signaling, Stat5b ...
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The Role of Interferon in Cancer Therapy: A Current Perspective
Ca-A Cancer Journal for Clinicians, 1988David S Goldstein +2 more
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Interferon regulatory factor-1 myelodysplasia and leukemia
Leukemia Research, 2006Dan A, Liebermann, Barbara, Hoffman
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Classics in Oncology: Virus Interference: I. The Interferon
Ca-A Cancer Journal for Clinicians, 1988Alick Isaacs, J Lindenmann, A Isaacs
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