Results 71 to 80 of about 9,208,925 (289)

Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-γ in Chinese Sturgeon Macrophages

Frontiers in Immunology, 2022
To further study the biological function of interferon-gamma (IFN-γ) in the Chinese sturgeon (Acipenser sinensis), we conducted a transcriptome analysis of primary macrophages induced by IFN-γ using Illumina sequencing technology.
Guangyi Ding, Chuwen Zheng, Bei Wang, Lifeng Zhang, Dan Deng, Qian Li, Huizhi Guo, Shuhuan Zhang, Qiaoqing Xu, Qiaoqing Xu   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An overview of the human immune system and the role of interferon regulatory factors (IRFs)

Progress in Microbes and Molecular Biology, 2020
The immune system consists of a dynamic network of cells, proteins, tissues, and organs that communicate to provide adequate defense responses against pathogenic agents. The immune system divide into the non-specific (innate) and the specific (adaptive)
Ashwinder Kaur, Chee-Mun Fang
doaj   +1 more source

The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster

Frontiers in Immunology, 2021
Interferon (IFN) system is considered as the first defense line against viral infection, and it has been extensively studied in vertebrates from fish to mammals. In invertebrates, Vagos from arthropod and IFN-like protein (CgIFNLP) from Crassostrea gigas
Xue Qiao, Xue Qiao, Xue Qiao, Yanan Zong, Yanan Zong, Yanan Zong, Zhaoqun Liu, Zhaoqun Liu, Zhaoqun Liu, Zhaojun Wu, Zhaojun Wu, Zhaojun Wu, Yuanmei Li, Yuanmei Li, Yuanmei Li, Lingling Wang, Lingling Wang, Lingling Wang, Lingling Wang, Lingling Wang, Linsheng Song, Linsheng Song, Linsheng Song, Linsheng Song, Linsheng Song   +24 more
doaj   +1 more source

Bunyaviruses and the type I interferon system [PDF]

, 2009
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Weber, F., Richard Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M.   +6 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Nuclear IL-33 amplifies NF-κB signaling to drive neutrophil recruitment and activation in the endocervical epithelium during Mycoplasma genitalium infection

Frontiers in Immunology
Mycoplasma genitalium has emerged as a clinically significant etiology of sexually transmitted infections that often establishes persistent infections within the female reproductive tract.
Yu Tian, Yu Tian, Kaiming Li, Kaiming Li, Na Xie, Chi Zhang, Hao Hu, Zhemin Huang, Min Du, Ranhui Li, Jing Xie   +10 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression.

PLoS Pathogens, 2019
Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) belongs to the subfamily of Gammaherpesvirinae and is the etiological agent of Kaposi's sarcoma as well as of two lymphoproliferative diseases: primary effusion lymphoma and multicentric
Sandra Koch, Modester Damas, Anika Freise, Elias Hage, Akshay Dhingra, Jessica Rückert, Antonio Gallo, Elisabeth Kremmer, Werner Tegge, Mark Brönstrup, Wolfram Brune, Thomas F Schulz   +11 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon
Hindle, Laura, L. M. Butler, K. Shah, Hindle, L, Lowry, K, S. A. Chanas, Mutocheluh, Mohamed, K. Lowry, Lowry, K., Shah, K., Chanas, Simon, Chanas, SA, D. J. Blackbourn, Areste, C., M. Mutocheluh, Aresté, C, Butler, Lucilla, Butler, LM, Shah, K, Blackbourn, DJ, L. Hindle, Blackbourn, David, C. Aresté, Chanas, S. A., Lowry, Kym, Mutocheluh, M, Blackbourn, D. J., Mutocheluh, M., Evans, DJ, Evans, David J., D. J. Evans, Hindle, L., Evans, D. J., Butler, L. M., Evans, D. J.; id_orcid   +34 more
core   +2 more sources